Liu Jiaxin, Zhu Zhiyuan, Leung Gilberto Ka-Kit
Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong SAR, China.
Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Guangzhou, China.
Front Cell Neurosci. 2022 Feb 14;16:818602. doi: 10.3389/fncel.2022.818602. eCollection 2022.
Intracerebral hemorrhage (ICH) is a devastating condition characterized by hematoma related mass effect. Microglia/macrophage (M φ) are rapidly recruited in order to remove the red blood cells through erythrophagocytosis. Efficient erythrophagocytosis can detoxify hemolytic products and facilitate neurological recovery after ICH. The underlying mechanisms include modulation of inflammatory response and oxidative stress, among others. It is a dynamic process mediated by a cascade of signal transduction, including "find-me" signals, "eat-me" signals and a set of phagocytotic receptors-ligand pairs that may be exploited as therapeutic targets. This review summarizes mechanistic signaling pathways of erythrophagocytosis and highlights the potential of harnessing M φ-mediated phagocytosis for ICH treatment.
脑出血（ICH）是一种具有血肿相关占位效应的毁灭性疾病。小胶质细胞/巨噬细胞（Mφ）会迅速被募集，以便通过红细胞吞噬作用清除红细胞。有效的红细胞吞噬作用可以使溶血产物解毒，并促进脑出血后的神经功能恢复。其潜在机制包括炎症反应和氧化应激的调节等。这是一个由一系列信号转导介导的动态过程，包括“找我”信号、“吃我”信号以及一组可作为治疗靶点的吞噬受体-配体对。本综述总结了红细胞吞噬作用的机制性信号通路，并强调了利用Mφ介导的吞噬作用治疗脑出血的潜力。
