关于异喹胍和普萘洛尔作用机制的纵向研究。
A longitudinal study of the mechanisms of action of debrisoquine and propranolol.
作者信息
Aminu J, Vere D W
出版信息
Br J Clin Pharmacol. 1978 Jul;6(1):43-50. doi: 10.1111/j.1365-2125.1978.tb01680.x.
1 The mode of action of hypotensive drugs is not necessarily the same early and late in a course of treatment. 2 It was aimed to study this possible difference of effects for the drugs debrisoquine and propranolol, using a clinical trial design and measuring as many cardiovascular functions as possible by noninvasive methods in out-patients. 3 Several well known effects of these drugs were noted; in addition it was found that in some subjects there was a small but progressive salt retention during propranolol treatment, that the displacements of the slopes in baroceptor function tests were different for the two drugs tested, and that venous distensibility was reduced at first with propranolol but soon increased again. 4 It is useful to combine longitudinal measures of body functions with a clinical trial when studying mechanisms of drug action.
- 降压药物的作用方式在治疗过程的早期和晚期不一定相同。2. 旨在通过临床试验设计，采用无创方法在门诊患者中尽可能多地测量心血管功能，研究去甲异喹胍和普萘洛尔这两种药物可能存在的效应差异。3. 记录了这些药物的几种众所周知的效应；此外还发现，在某些受试者中，普萘洛尔治疗期间存在少量但逐渐增加的盐潴留现象，两种受试药物在压力感受器功能测试中的斜率变化不同，并且普萘洛尔最初会降低静脉扩张性，但很快又会再次升高。4. 在研究药物作用机制时，将身体功能的纵向测量与临床试验相结合是有用的。
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