Universidade Federal Rural de Pernambuco, Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia (Recife/PE, Brazil).
Universidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Laboratório de Biologia Molecular-CEONHPE (Recife/PE, Brazil).
Dental Press J Orthod. 2022 Feb 28;27(1):e2220159. doi: 10.1590/2177-6709.27.1.e2220159.oar. eCollection 2022.
Temporomandibular disorder (TMD) refers to a group of conditions that compromise the harmonious movement and function of the temporomandibular joint, masticatory muscles, and associated structures. The etiopathogenesis of TMD is multifactorial but not well-understood, with the role of genetic factors still being unclear.
This review aims to summarize the results of studies that evaluated TNF-α levels and the -308G/A TNF-α polymorphism in TMD patients. This study emphasizes the importance of a more selective treatment involving TNF-α inhibitors that can potentially reduce inflammation and pain, and improve quality of life.
The MEDLINE/PubMed database, Cochrane Library, and Web of Science database were searched for case-control studies published until September 2020 that compared levels of TNF-α or presence of its -308G/A polymorphism in TMD patients and healthy individuals.
Six case-control studies were identified with a total of 398 TMD patients, aged between 12 and 78 years. The control group consisted of 149 subjects, aged between 18 and 47 years. The occurrence of TMD was predominant in females. Majority of studies found high TNF-α levels in TMD patients, compared to the control group. One of these studies found a positive correlation between the GA genotype and the development of TMD.
Majority of the TMD patients showed elevated TNF-α levels, and a possible explanation for this could be the presence of the -308G/A polymorphism.
颞下颌关节紊乱（TMD）是一组影响颞下颌关节、咀嚼肌及相关结构协调运动和功能的疾病。TMD 的病因学是多因素的，但目前尚未完全清楚，遗传因素的作用仍不清楚。
本综述旨在总结评估 TMD 患者 TNF-α 水平和 -308G/A TNF-α 多态性的研究结果。该研究强调了使用 TNF-α 抑制剂进行更有针对性治疗的重要性，这种治疗方法可能减轻炎症和疼痛，提高生活质量。
检索 MEDLINE/PubMed 数据库、Cochrane 图书馆和 Web of Science 数据库，截至 2020 年 9 月，纳入比较 TMD 患者和健康个体 TNF-α 水平或 -308G/A TNF-α 多态性的病例对照研究。
共纳入 6 项病例对照研究，共 398 例 TMD 患者，年龄 12 至 78 岁；对照组 149 例，年龄 18 至 47 岁。TMD 以女性多见。与对照组相比，大多数研究发现 TMD 患者的 TNF-α 水平较高。其中一项研究发现 GA 基因型与 TMD 的发生呈正相关。
大多数 TMD 患者的 TNF-α 水平升高，其可能的解释是存在 -308G/A 多态性。
