Zeng Jiuseng, Luan Fei, Hu Jingwen, Liu Yao, Zhang Xiumeng, Qin Tiantian, Zhang Xia, Liu Rong, Zeng Nan
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Sichuan 611137, PR China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, PR China.
Int J Biol Macromol. 2022 May 1;206:325-354. doi: 10.1016/j.ijbiomac.2022.02.138. Epub 2022 Mar 1.
Undaria pinnatifida, one of the most widespread seafood consumed in China and many other nations, has been traditionally utilized as an effective therapeutically active substance for edema, phlegm elimination and diuresis, and detumescence for more than 2000 years. Numerous studies have found that polysaccharides of U. pinnatifida play an indispensable role in the nutritional and medicinal value. The water extraction and alcohol precipitation method are the most used method. More than 40 U. pinnatifida polysaccharides (UPPs) were successfully isolated and purified from U. pinnatifida, whereas only few of them were well characterized. Pharmacological studies have shown that UPPs have high-order structural features and multiple biological activities, including anti-tumor, antidiabetic, immunomodulatory, antiviral, anti-inflammatory, antioxidant, anticoagulating, antithrombosis, antihypertension, antibacterial, and renoprotection. In addition, the structural characteristics of UPPs are closely related to their biological activity. In this review, the extraction and purification methods, structural characteristics, biological activities, clinical settings, toxicities, structure-activity relationships and industrial application of UPPs are comprehensively summarized. The structural characteristics and biological activities as well as the underlying molecular mechanisms of UPPs were also outlined. Furthermore, the clinical settings and structure-activity functions of UPPs were highlighted. Some research perspectives and challenges in the study of UPPs were also proposed.
裙带菜是中国和许多其他国家消费最为广泛的海产品之一，在2000多年的时间里，一直被传统地用作治疗水肿、化痰、利尿和消肿的有效治疗活性物质。众多研究发现，裙带菜多糖在其营养和药用价值中发挥着不可或缺的作用。水提取和醇沉淀法是最常用的方法。已成功从裙带菜中分离纯化出40多种裙带菜多糖（UPPs），但其中只有少数得到了充分表征。药理学研究表明，UPPs具有高阶结构特征和多种生物活性，包括抗肿瘤、抗糖尿病、免疫调节、抗病毒、抗炎、抗氧化、抗凝、抗血栓形成、抗高血压、抗菌和肾脏保护作用。此外，UPPs的结构特征与其生物活性密切相关。在本综述中，全面总结了UPPs的提取和纯化方法、结构特征、生物活性、临床应用、毒性、构效关系及工业应用。还概述了UPPs的结构特征和生物活性以及潜在的分子机制。此外，突出了UPPs的临床应用和构效功能。还提出了UPPs研究中的一些研究前景和挑战。
