State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Sichuan 611137, P. R. China.
Food Funct. 2021 May 21;12(10):4254-4283. doi: 10.1039/d1fo00311a. Epub 2021 Apr 27.
Laminaria japonica, one of the most widespread seafood consumed in China and many other nations, has been traditionally utilized as an effective therapeutically active substance for treating weight loss, phlegm elimination, and detumescence for more than 2000 years. Numerous studies have found that the polysaccharides play an indispensable role in the nutritional and medicinal value of L. japonica. Water extraction and alcohol precipitation method is the most used method. Approximately 56 LJPs were successfully isolated and purified from L. japonica, whereas only few of them were well characterized. Modern pharmacological studies have shown that L. japonica polysaccharides (LJPs) have high-order structural features and multiple biological activities, including anti-tumor, anti-thrombotic, anti-atherosclerosis, hypolipidemic, hypoglycemic, antioxidant, anti-inflammatory, renoprotective, and immunomodulatory. In addition, the structural characteristics of LJPs are closely related to their biological activity. In this review, the extraction and purification methods, structural characteristics, biological activities, clinical settings, toxicities, and structure-activity relationships of LJPs are comprehensively summarized. The structural characteristics and biological activities as well as the underlying molecular mechanisms of LJPs were also outlined. Furthermore, the clinical settings and structure-activity functions of LJPs were highlighted. Some research perspectives and challenges in the study of LJPs were also proposed.
裙带菜是中国和许多其他国家广泛食用的海鲜之一，作为一种有效的治疗活性物质，已被传统应用于治疗减肥、化痰和消肿超过 2000 年。许多研究发现，多糖在裙带菜的营养价值和药用价值中起着不可或缺的作用。水提法和醇沉法是最常用的方法。从裙带菜中成功分离和纯化了约 56 种 LJPs，但只有少数几种得到了很好的表征。现代药理学研究表明，裙带菜多糖（LJPs）具有高级结构特征和多种生物活性，包括抗肿瘤、抗血栓、抗动脉粥样硬化、降血脂、降血糖、抗氧化、抗炎、肾保护和免疫调节。此外，LJPs 的结构特征与其生物活性密切相关。在这篇综述中，综合总结了 LJPs 的提取和纯化方法、结构特征、生物活性、临床应用、毒性以及结构-活性关系。还概述了 LJPs 的结构特征和生物活性以及潜在的分子机制。此外，还强调了 LJPs 的临床应用和结构-活性功能。还提出了 LJPs 研究中的一些研究观点和挑战。
