血清血管紧张素转换酶在肉样瘤病中的诊断和分期价值。

Diagnostic and Staging Value of Serum Angiotensin-Converting Enzyme in Sarcoidosis.

机构信息

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Beijing 100029, China.

Respiratory Department of Tianjin Beichen Hospital, Tianjin 300400, China.

出版信息

Comput Math Methods Med. 2022 Feb 22;2022:4657502. doi: 10.1155/2022/4657502. eCollection 2022.

DOI:10.1155/2022/4657502

PMID:35242207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8888048/

Abstract

OBJECTIVE

To investigate the diagnostic and staging value of serum angiotensin-converting enzyme (sACE) in sarcoidosis.

METHODS

Patients with suspected sarcoidosis treated in the Department of Pulmonary and Critical Care Medicine of the China-Japan Friendship Hospital from 2010 to 2020 were included. The data of sACE, erythrocyte sedimentation rate (ESR), complete blood count (CBC), lung function, bronchoalveolar lavage, and biopsy were collected. The differences between the sarcoidosis group and the nonsarcoidosis group and between different stages of sarcoidosis were compared. The receiver operating characteristic (ROC) curve analysis was used for the diagnostic test of sACE in sarcoidosis.

RESULTS

A total of 84 cases with suspected sarcoidosis were included, among which 70 cases were confirmed to be sarcoidosis by biopsy. The mean value of sACE in sarcoidosis patients was 56.61 ± 30.80 U/L, which was significantly higher than that in nonsarcoidosis patients (28.07 ± 14.11 U/L, = 0.001). The level of sACE in sarcoidosis patients with peripheral superficial lymph nodes and multiple system involvement was significantly higher than that in intrathoracic sarcoidosis patients ( = 0.009); the percentage of lymphocytes in bronchoalveolar lavage fluid (BALF) of sarcoidosis patients was 45.39 ± 22.87%, which was significantly higher than that of nonsarcoidosis patients ( < 0.001). There was no correlation between sACE and ESR (correlation coefficient = -0.167). According to ROC curve analysis, when sACE ≥ 44.0 U/L, the sensitivity of sarcoidosis diagnosis was 61.4%, the specificity was 92.9%, and the AUC was 0.819.

CONCLUSION

sACE has a good specificity in the diagnosis of sarcoidosis. sACE values in patients with sarcoidosis with systemic involvement were higher than those with simple intrathoracic sarcoidosis.

摘要

目的

探讨血清血管紧张素转换酶（sACE）在结节病中的诊断和分期价值。

方法

纳入 2010 年至 2020 年期间在中国医学科学院北京协和医院呼吸与危重症医学科就诊的疑似结节病患者。收集 sACE、红细胞沉降率（ESR）、全血细胞计数（CBC）、肺功能、支气管肺泡灌洗和活检等数据。比较结节病组与非结节病组以及不同分期结节病患者之间的差异。采用受试者工作特征（ROC）曲线分析 sACE 对结节病的诊断价值。

结果

共纳入 84 例疑似结节病患者，其中 70 例经活检确诊为结节病。结节病患者的 sACE 平均值为 56.61 ± 30.80 U/L，明显高于非结节病患者（28.07 ± 14.11 U/L， = 0.001）。伴有外周浅表淋巴结和多系统受累的结节病患者 sACE 水平明显高于单纯胸内结节病患者（ = 0.009）；结节病患者支气管肺泡灌洗液（BALF）中淋巴细胞百分比为 45.39 ± 22.87%，明显高于非结节病患者（ < 0.001）。sACE 与 ESR 无相关性（相关系数 = -0.167）。根据 ROC 曲线分析，当 sACE≥44.0 U/L 时，结节病诊断的敏感性为 61.4%，特异性为 92.9%，AUC 为 0.819。