Ferro Desideri Lorenzo, Rosa Raffaella, Musetti Donatella, Vagge Aldo, Vena Antonio, Bassetti Matteo, Traverso Carlo Enrico, Nicolò Massimo
University Eye Clinic of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy.
Am J Ophthalmol Case Rep. 2022 Feb 17;26:101434. doi: 10.1016/j.ajoc.2022.101434. eCollection 2022 Jun.
Ocular syphilis is also known as the 'great masquerader' for the wide variety of clinical features associated with this infection. Although chorioretinitis represents the most frequent manifestation in the posterior pole, other clinical entities can be described, including retinal vasculitis, optic disc disorders, necrotizing vasculitis and acute syphilitic posterior placoid chorioretinopathy (ASPPC). This latter is an infrequent ocular manifestation of syphilis, whose pathophysiology remains still unknown; however, multimodal imaging, including optical coherence tomography angiography (OCTA), has enabled us to better describe its pathophysiology and clinical course. In this study we report a case series of 3 different patients with syphilis-related chorioretinopathies; in this regard, the role of multimodal imaging has emerged has an extremely useful approach in order to better understand the pathophysiology of syphilitic chorioretinopathies. This could help clinicians (both ophthalmologist and infectious disease specialists) to early treat and prevent the severe ocular complications related to this fearsome disease.
由于与这种感染相关的临床特征多种多样，眼部梅毒也被称为“伪装大师”。虽然脉络膜视网膜炎是后极部最常见的表现，但也可以描述其他临床病症，包括视网膜血管炎、视盘疾病、坏死性血管炎和急性梅毒性后极部扁平状脉络膜视网膜炎（ASPPC）。后者是梅毒罕见的眼部表现，其病理生理学仍然未知；然而，包括光学相干断层扫描血管造影（OCTA）在内的多模态成像使我们能够更好地描述其病理生理学和临床过程。在本研究中，我们报告了3例不同的梅毒相关性脉络膜视网膜炎患者的病例系列；在这方面，多模态成像已成为一种极其有用的方法，以便更好地理解梅毒性脉络膜视网膜炎的病理生理学。这有助于临床医生（眼科医生和传染病专家）早期治疗并预防与这种可怕疾病相关的严重眼部并发症。
