The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, Australia.
Cancer Council NSW, Sydney, NSW, Australia.
BMC Res Notes. 2022 Mar 4;15(1):88. doi: 10.1186/s13104-022-05970-z.
Menopausal status impacts risk for many health outcomes. However, factors including hysterectomy without oophorectomy and Menopausal Hormone Therapy (MHT) can mask menopause, affecting reliability of self-reported menopausal status in surveys. We describe a step-by-step algorithm for classifying menopausal status using: directly self-reported menopausal status; MHT use; hysterectomy; oophorectomy; intervention timing; and attained age. We illustrate this approach using the Australian 45 and Up Study cohort (142,973 women aged ≥ 45 years).
We derived a detailed seven-category menopausal status, able to be further consolidated into four categories ("pre-menopause"/"peri-menopause"/"post-menopause"/"unknown") accounting for participants' ages. 48.3% of women had potentially menopause-masking interventions. Overall, 93,107 (65.1%), 9076 (6.4%), 17,930 (12.5%) and 22,860 (16.0%) women had a directly self-reported "post-menopause", "peri-menopause", "pre-menopause" and "not sure"/missing status, respectively. 61,464 women with directly self-reported "post-menopause" status were assigned a "natural menopause" detailed derived status (menopause without MHT use/hysterectomy/oophorectomy). By accounting for participants' ages, 105,817 (74.0%) women were assigned a "post-menopause" consolidated derived status, including 15,009 of 22,860 women with "not sure"/missing directly self-reported status. Conversely, 3178 of women with directly self-reported "post-menopause" status were assigned "unknown" consolidated derived status. This algorithm is likely to improve the accuracy and reliability of studies examining outcomes impacted by menopausal status.
绝经状态会影响许多健康结果的风险。然而，包括子宫切除而未切除卵巢和激素替代疗法（MHT）在内的因素会掩盖绝经，从而影响调查中自我报告的绝经状态的可靠性。我们描述了一种使用以下方法对绝经状态进行分类的逐步算法：直接自我报告的绝经状态；MHT 使用情况；子宫切除术；卵巢切除术；干预时机；和达到的年龄。我们使用澳大利亚 45 岁及以上研究队列（142973 名年龄≥45 岁的女性）来说明这种方法。
我们得出了一个详细的七类绝经状态，可以进一步合并为四个类别（“绝经前”/“围绝经期”/“绝经后”/“未知”），以说明参与者的年龄。48.3%的女性存在潜在的绝经掩盖干预措施。总的来说，93107（65.1%）、9076（6.4%）、17930（12.5%）和 22860（16.0%）的女性直接自我报告的“绝经后”、“围绝经期”、“绝经前”和“不确定/缺失”状态分别为 93107（65.1%）、9076（6.4%）、17930（12.5%）和 22860（16.0%）。61464 名直接自我报告“绝经后”状态的女性被分配了一个“自然绝经”详细的衍生状态（无 MHT 使用/子宫切除术/卵巢切除术的绝经）。通过考虑参与者的年龄，105817 名女性（74.0%）被分配了一个“绝经后”的综合衍生状态，其中包括 22860 名女性中有 15009 名直接报告的“不确定/缺失”状态。相反，3178 名直接报告“绝经后”状态的女性被分配了“未知”的综合衍生状态。这种算法可能会提高研究绝经状态对影响结果的准确性和可靠性。
