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脂蛋白(a)升高和 LPA 基因的遗传多态性可能预测心血管事件。

Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events.

机构信息

Department of Clinical Laboratory, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, People's Republic of China.

Department of Traditional Chinese Medicine, Peking University International Hospital, Beijing, People's Republic of China.

出版信息

Sci Rep. 2022 Mar 4;12(1):3588. doi: 10.1038/s41598-022-07596-4.

DOI:10.1038/s41598-022-07596-4
PMID:35246583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8897417/
Abstract

Elevated lipoprotein(a) [Lp(a)] is a risk factor for coronary heart disease (CHD), but there are few studies on the prediction of future cardiovascular events by Lp(a) and its LPA single nucleotide polymorphisms (SNPs). The aim of this study was to investigate whether elevated Lp(a) and its SNPs can predict cardiovascular events. We evaluated whether Lp(a) and LPA SNPs rs6415084 and rs12194138 were associated with the incidence rate and severity of CHD. All participants were followed up for 5 years. Elevated Lp(a) is an independent risk factor for the risk and severity of CHD (CHD group vs. control group: OR = 1.793, 95% CI: 1.053-2.882, p = 0.043; multiple-vessel disease group vs. single-vessel disease group: OR = 1.941, 95% CI: 1.113-3.242, p = 0.027; high GS group vs. low GS group: OR = 2.641, 95% CI: 1.102-7.436, p = 0.040). Both LPA SNPs were risk factors for CHD, and were positively associated with the severity of CHD (LPA SNPs rs6415084: CHD group vs. control group: OR = 1.577, 95% CI: 1.105-1.989, p = 0.004; multiple-vessel disease group vs. single-vessel disease group: OR = 1.613, 95% CI: 1.076-2.641, p = 0.030; high GS group vs. low GS group: OR = 1.580, 95% CI: 1.088-2.429, p = 0.024; LPA SNPs rs12194138: CHD group vs. control group: OR = 1.475, 95% CI: 1.040-3.002, p = 0.035; multiple-vessel disease group vs. single-vessel disease group: OR = 2.274, 95% CI: 1.060-5.148, p = 0.038; high GS group vs. low GS group: OR = 2.067, 95% CI: 1.101-4.647, p = 0.021). After 5 years of follow-up, elevated Lp(a) and LPA SNPs rs6415084 and rs12194138 can independently predict cardiovascular events. The increase of serum Lp(a) and LPA SNPs rs6415084 and rs12194138 are associated with increased prevalence and severity of CHD, and can independently predict cardiovascular events.

摘要

脂蛋白(a)[Lp(a)]升高是冠心病(CHD)的危险因素，但关于 Lp(a)及其脂蛋白(a)单核苷酸多态性(SNPs)对未来心血管事件的预测研究较少。本研究旨在探讨升高的 Lp(a)及其 SNPs 是否可以预测心血管事件。我们评估了 Lp(a)和 LPA SNPs rs6415084 和 rs12194138 是否与 CHD 的发生率和严重程度相关。所有参与者均随访 5 年。升高的 Lp(a)是 CHD 风险和严重程度的独立危险因素(CHD 组与对照组：OR=1.793，95%CI：1.053-2.882，p=0.043；多血管疾病组与单血管疾病组：OR=1.941，95%CI：1.113-3.242，p=0.027；高 GS 组与低 GS 组：OR=2.641，95%CI：1.102-7.436，p=0.040)。两个 LPA SNPs 都是 CHD 的危险因素，与 CHD 的严重程度呈正相关(LPA SNPs rs6415084：CHD 组与对照组：OR=1.577，95%CI：1.105-1.989，p=0.004；多血管疾病组与单血管疾病组：OR=1.613，95%CI：1.076-2.641，p=0.030；高 GS 组与低 GS 组：OR=1.580，95%CI：1.088-2.429，p=0.024；LPA SNPs rs12194138：CHD 组与对照组：OR=1.475，95%CI：1.040-3.002，p=0.035；多血管疾病组与单血管疾病组：OR=2.274，95%CI：1.060-5.148，p=0.038；高 GS 组与低 GS 组：OR=2.067，95%CI：1.101-4.647，p=0.021)。经过 5 年的随访，升高的 Lp(a)和 LPA SNPs rs6415084 和 rs12194138 可独立预测心血管事件。血清 Lp(a)和 LPA SNPs rs6415084 和 rs12194138 的增加与 CHD 的患病率和严重程度增加相关，并且可以独立预测心血管事件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/cbbdbcc26d64/41598_2022_7596_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/9d55e6b34384/41598_2022_7596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/a3c71bc50701/41598_2022_7596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/b2bc79a81d7d/41598_2022_7596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/cbbdbcc26d64/41598_2022_7596_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/9d55e6b34384/41598_2022_7596_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/a3c71bc50701/41598_2022_7596_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/b2bc79a81d7d/41598_2022_7596_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aa1/8897417/cbbdbcc26d64/41598_2022_7596_Fig4_HTML.jpg

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[5]
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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
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Eur Heart J. 2021-6-7

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