National Institute for Health and Care Excellence (NICE), Manchester, UK.
NHS England and NHS Improvement, Medicines Repurposing Program, London, UK.
Qual Life Res. 2022 Jul;31(7):2167-2173. doi: 10.1007/s11136-022-03101-6. Epub 2022 Mar 5.
In July 2019, the National Institute for Health and Care Excellence (NICE) initiated a major review of its health technology evaluation methods to update its methods guide. This update has recently concluded with the publication of its health technology evaluation manual in January 2022. This paper reports the methods and findings of the review in relation to the recommended approach to use for the measurement and valuation of health-related quality of life (HRQoL) in submissions to NICE. Issues related to (i) the methods to use when NICE's preferred measure (EQ-5D) is not appropriate or not available; (ii) adjusting health state utility values over time to account for age; (iii) measuring and valuing HRQoL in children and young people; and (iv) including carers' QoL in economic evaluations were included in this review. This commentary summarises the methods used to undertake the review, its findings, and the changes to NICE methods that were proposed based on these findings. It also outlines topics where further research is needed before definitive methods guidance can be issued. The broad proposals described here were subject to a public consultation in 2020 and a further consultation on the updated methods guidance was completed in October 2021 before the publication of the manual in January 2022.
2019 年 7 月，英国国家卫生与保健优化研究所（NICE）启动了对其卫生技术评估方法的重大审查，以更新其方法指南。最近，该指南的更新工作已经完成，并于 2022 年 1 月发布了《卫生技术评估手册》。本文报告了此次审查的方法和结果，涉及 NICE 建议用于提交评估的健康相关生命质量（HRQoL）测量和估值的方法。审查涉及到以下问题：(i) 在 NICE 首选测量方法（EQ-5D）不适用或不可用时使用何种方法；(ii) 随时间调整健康状态效用值以反映年龄变化；(iii) 在儿童和青少年中测量和估值 HRQoL；以及 (iv) 将照顾者的生命质量纳入经济评估。本评论总结了进行审查所使用的方法、发现结果以及基于这些发现对 NICE 方法提出的修改建议。它还概述了在发布明确的方法指南之前需要进一步研究的主题。这里描述的广泛建议在 2020 年进行了公众咨询，2021 年 10 月完成了对更新方法指南的进一步咨询，随后于 2022 年 1 月发布了《手册》。
