Forest J C, Larivière F, Dolcé P, Masson M, Nadeau L
Clin Biochem. 1986 Jun;19(3):192-4. doi: 10.1016/s0009-9120(86)80023-6.
Serial quantitative measurements of C-reactive protein (CRP) were performed, using an automated enzyme immunoassay method, in 127 neonates (114 premature and 13 full-term) classified in three groups: neonates with a normal postnatal course (group 1, n = 69), neonates with clinical suspicion of bacterial infection but with negative cultures (group 2, n = 49), and neonates with proven bacterial infection (group 3, n = 9). A total of 545 serial serum CRP concentrations were determined. In group 1, CRP concentrations were below the detection limit of the method (10 mg/L) except in one neonate who suffered from neonatal anoxia but whose clinical course was uncomplicated (CRP: 31 mg/L within 24 h of life). Thirty-three neonates of group 2 had CRP values consistently below 10 mg/L while 16 had elevated CRP concentrations at least on one occasion ranging from 10 to 70 mg/L. Diagnoses other than bacterial infection could explain the raised CRP concentrations in neonates of group 2. CRP concentrations were found to be elevated (greater than 80 mg/L) during the course of infectious diseases in all neonates with proven bacterial infection (septicemia (4), pneumonia (1), multiple micro-abscesses (1), urinary tract infection (3]. Serial measurement of CRP concentrations are shown to be valuable in detecting bacterial infection in neonates as well as in following the efficacy of antimicrobial therapy.
采用自动酶免疫分析法，对127例新生儿（114例早产儿和13例足月儿）进行了C反应蛋白（CRP）的系列定量检测，这些新生儿分为三组：出生后病程正常的新生儿（第1组，n = 69）、临床怀疑有细菌感染但培养结果为阴性的新生儿（第2组，n = 49）以及已证实有细菌感染的新生儿（第3组，n = 9）。共测定了545个系列血清CRP浓度。在第1组中，除1例患有新生儿缺氧但临床病程无并发症的新生儿（出生后24小时内CRP：31mg/L）外，CRP浓度均低于该方法的检测限（10mg/L）。第2组的33例新生儿CRP值持续低于10mg/L，而16例至少有一次CRP浓度升高，范围为10至70mg/L。除细菌感染外的其他诊断可以解释第2组新生儿CRP浓度升高的原因。在所有已证实有细菌感染的新生儿（败血症（4例）、肺炎（1例）、多发性微脓肿（1例）、尿路感染（3例））的传染病病程中，均发现CRP浓度升高（大于80mg/L）。CRP浓度的系列检测在检测新生儿细菌感染以及监测抗菌治疗效果方面显示出价值。
