Blayney A W, Romero Rio J A, Williams K R, Guilhaume A, Bagot D'Arc M, Portmann M
Clin Otolaryngol Allied Sci. 1986 Jun;11(3):189-97. doi: 10.1111/j.1365-2273.1986.tb00127.x.
The biocompatibility of vitreous carbon and carbon fibre reinforced carbon (CFRC) as middle ear implants was investigated. In separate animal model systems, vitreous carbon was implanted in the middle ear of 20 DA rats for up to 6 months, whilst 3 varieties of CFRC (basic or crude, ultrasonically cleaned, glazed) were implanted in 98 guinea-pig middle ears for up to 4 months. Tissue reactions to implantation were assessed by means of stereoscopic and standard light microscopy, and scanning electron microscopy with chemical analysis facilities (EDAX, WDAX). Vitreous carbon and glazed CFRC were considered suitable for human implantation and a trial of the latter was started in 23 patients (14 partial, 9 total ossicular implants). At 9 months, only 52% of the implants were still in situ; 40% had been extruded and 8% had elicited inflammatory responses which would undoubtedly result in extrusion. Carbon particle dissemination with carbon fibre destruction and exposure as a result of peroperative prosthesis drilling were considered the likely causes for the failure of this implant.
研究了玻璃碳和碳纤维增强碳（CFRC）作为中耳植入物的生物相容性。在不同的动物模型系统中，将玻璃碳植入20只DA大鼠的中耳长达6个月，同时将3种CFRC（基础型或粗制型、超声清洁型、釉面型）植入98只豚鼠的中耳长达4个月。通过立体显微镜和标准光学显微镜以及带有化学分析设备（能谱仪、波谱仪）的扫描电子显微镜评估植入后的组织反应。玻璃碳和釉面CFRC被认为适合人体植入，并于23例患者（14例部分听小骨植入、9例全听小骨植入）中开展了后者的试验。9个月时，仅有52%的植入物仍在位；40%已被挤出，8%引发了炎症反应，这无疑会导致挤出。术中假体钻孔导致碳颗粒扩散以及碳纤维破坏和暴露被认为是该植入物失败的可能原因。
