Department of Urology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh, 226003, India.
Department of Thoracic Surgery, King George's Medical University, Lucknow, UP, 226003, India.
Mol Biol Rep. 2022 Jul;49(7):6753-6762. doi: 10.1007/s11033-022-07308-1. Epub 2022 Mar 6.
The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.
The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.
Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.
2019 年冠状病毒病（COVID-19）的爆发严重影响了全球健康和经济状况。血管紧张素转换酶 2（ACE2）和 S 蛋白的天然受体-配体相互作用通过免疫抑制引起宿主细胞发病机制。
新出现的证据报告了 COVID-19 导致的死亡率存在性别差异，这对男性人口产生了巨大影响。尽管 COVID-19 与受体的生物学相互作用上调了病毒基因组蛋白的相互作用，并在 COVID-19 感染的男性人群中引发了预测性多器官衰竭，随后是急性肾损伤（AKI）。
此外，从研究中获得的知识和经验教训表明，细胞和分子联系可以解释 COVID-19 和 AKI 在男性人群中的风险和严重程度，并导致 COVID-19 诱导的 AKI 的管理。因此，本综述探讨了与两种性别差异疾病发病机制相关的途径。
