Geetha V, Kumar G Suresh
Department of Biochemistry, CSIR- Central Food Technological Research Institute, Mysuru, 570020 India.
J Food Sci Technol. 2022 Apr;59(4):1649-1657. doi: 10.1007/s13197-021-05178-2. Epub 2021 Jul 21.
The present study involved feeding of tender coconut water concentrate (TCW) and testa phenolic concentrate (PHE) to high fat fed animals. Analysis of serum showed increased HDL-C in concentrates treated group and therefore higher protection against atherogenesis compared to high fat fed group. Lesser fecal fat content and higher level of liver cholesterol were observed in high fat fed group, treatments with TCW and PHE ameliorated significantly. Fat content in the organs (liver, heart, kidney and adipose) of HFD group was high. Furthermore, certain fatty acids observed in the tissues were 14:0, 16:0, 18:0, 18:1, 18:2, 20:0, 20:3 and 20:4, among which 14:0, 16:0 & 18:0 are the major saturated fatty acids that increased significantly in high fat fed group when compared with starch fed group and ameliorated with TCW and PHE dose dependently. These results clearly indicate both the concentrates (TCW and PHE) restrict excess accumulation of lipids and altered composition of fatty acids in tissues as well as serum which are the risk factors for development of insulin resistance, hyperlipidemia, dyslipidemia etc., related to obesity.
The online version contains supplementary material available at 10.1007/s13197-021-05178-2.
本研究对高脂喂养的动物投喂嫩椰子水浓缩物（TCW）和种皮酚浓缩物（PHE）。血清分析显示，浓缩物处理组的高密度脂蛋白胆固醇（HDL-C）增加，因此与高脂喂养组相比，对动脉粥样硬化的保护作用更强。高脂喂养组的粪便脂肪含量较低，肝脏胆固醇水平较高，而TCW和PHE处理可显著改善这些情况。高脂饮食（HFD）组各器官（肝脏、心脏、肾脏和脂肪组织）中的脂肪含量较高。此外，在组织中观察到的某些脂肪酸为14:0、16:0、18:0、18:1、18:2、20:0、20:3和20:4，其中14:0、16:0和18:0是主要的饱和脂肪酸，与淀粉喂养组相比，高脂喂养组中这些脂肪酸显著增加，而TCW和PHE可使其剂量依赖性改善。这些结果清楚地表明，两种浓缩物（TCW和PHE）均能限制组织和血清中脂质的过度积累以及脂肪酸组成的改变，而这些都是与肥胖相关的胰岛素抵抗、高脂血症、血脂异常等疾病发展的危险因素。
在线版本包含可在10.1007/s13197-021-05178-2获取的补充材料。
