Vandewalker M L, Kray K T, Weber R W, Nelson H S
Chest. 1986 Aug;90(2):198-203. doi: 10.1378/chest.90.2.198.
The efficacy and side effects of oral or inhaled terbutaline were examined in 13 mild-to-moderate asthmatic patients (ages 12 to 71 years) on maintenance theophylline (levels 10 to 25 micrograms/ml). In a crossover design, each patient received for two weeks oral terbutaline, 5 mg qid, inhaled terbutaline, 400 micrograms qid, or identical placebo tablets or metered-dose inhalers. Prior to each double-blind period, terbutaline was given for two weeks to ensure development of beta-adrenergic subsensitivity. Home-monitored peak flows and need for supplementary bronchodilators were significantly improved with both oral and inhaled terbutaline, but only the inhaled drug significantly decreased symptoms. Long-term terbutaline, either oral or inhaled, added to maintenance theophylline improved the patients' pulmonary function. The inhaled drug also improved the patients' clinical status as reflected by asthma symptom scores and need for extra bronchodilator. Combining terbutaline with theophylline did not produce evidence of cardiotoxicity.
在13名维持服用氨茶碱（血药浓度为10至25微克/毫升）的轻至中度哮喘患者（年龄12至71岁）中，研究了口服或吸入特布他林的疗效和副作用。采用交叉设计，每位患者接受为期两周的治疗，分别为口服特布他林（5毫克，每日4次）、吸入特布他林（400微克，每日4次），或相同的安慰剂片剂或定量吸入器。在每个双盲期之前，先给予特布他林两周，以确保β-肾上腺素能敏感性降低。口服和吸入特布他林均显著改善了家庭监测的峰值呼气流速以及使用补充支气管扩张剂的需求，但只有吸入药物显著减轻了症状。长期口服或吸入特布他林并联合维持剂量的氨茶碱可改善患者的肺功能。吸入药物还改善了患者的临床状况，这体现在哮喘症状评分和额外使用支气管扩张剂的需求上。特布他林与氨茶碱联合使用未产生心脏毒性证据。
