Pathak Neil, Radford Zachary J, Kahan Joseph B, Grauer Jonathan N, Rubin Lee E
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA.
Arthroplast Today. 2022 Feb 28;14:76-80. doi: 10.1016/j.artd.2021.12.009. eCollection 2022 Apr.
Public interest in alternative, nonoperative treatments for the management of arthritis has increased. Few have been approved by the Food and Drug Administration. The present study aimed to evaluate trends in public and scientific interest in 4 such treatments by assessing Google Trends and publication frequency data, respectively.
Turmeric, stem cell therapy, platelet-rich plasma (PRP) therapy, and cannabidiol (CBD) were studied. For 2010-2019, Google Trends data and publication frequency data on PubMed were collected by year for arthritis and each of the 4 therapies. Linear, quadratic, and exponential regressions were applied, and the best model of growth was identified.
From 2010 to 2019, Google Trends annual scores for arthritis and turmeric (exponential; R: 90.5%, < .001), CBD (exponential; R: 99.3%, < .001), stem cell therapy (exponential; R: 86.7%, < .001), and PRP therapy (linear; R: 80.6%, < .001) increased significantly. Search term frequencies for arthritis and CBD exhibited the highest increase (12,929%). Publications in arthritis and turmeric (linear; R: 74%, = .001), stem cell therapy (linear; R: 94.8%, < .0001), and PRP therapy (linear; R: 97.1%, < .0001) increased from 2010 to 2019. However, publications relating to arthritis and CBD have not increased ( = .122).
Regression analysis indicates that public interest in alternative therapies have had a marked increase. The rise in public interest for CBD, and to a lesser extent, turmeric, stem cell therapy, and PRP, has dramatically outstripped scientific evidence on these therapies. Rigorously designed, clinical studies may be beneficial to keep up with the growing popularity of these treatments, especially CBD.
公众对关节炎非手术替代治疗方法的兴趣有所增加。但很少有此类疗法获得美国食品药品监督管理局的批准。本研究旨在分别通过评估谷歌趋势和发表频率数据，来评估公众和科学界对4种此类治疗方法的兴趣趋势。
对姜黄、干细胞疗法、富血小板血浆（PRP）疗法和大麻二酚（CBD）进行了研究。收集了2010 - 2019年每年关于关节炎以及这4种疗法各自在谷歌趋势上的数据和PubMed上的发表频率数据。应用了线性、二次和指数回归分析，并确定了最佳增长模型。
2010年至2019年期间，关节炎、姜黄（指数模型；R：90.5%，P <.001）、CBD（指数模型；R：99.3%，P <.001）、干细胞疗法（指数模型；R：86.7%，P <.001）以及PRP疗法（线性模型；R：80.6%，P <.001）的谷歌趋势年度得分均显著增加。关节炎和CBD搜索词频率的增幅最大（12,929%）。2010年至2019年期间，关节炎与姜黄（线性模型；R：74%，P =.001）、干细胞疗法（线性模型；R：94.8%，P <.0001）以及PRP疗法（线性模型；R：97.1%，P <.0001）相关的出版物数量有所增加。然而，与关节炎和CBD相关的出版物数量并未增加（P =.122）。
回归分析表明公众对替代疗法的兴趣显著增加。公众对CBD以及程度稍低的姜黄、干细胞疗法和PRP的兴趣增长，已大大超过了关于这些疗法的科学证据。严格设计的临床研究可能有助于跟上这些治疗方法日益增长的普及程度，尤其是CBD。
