Zampetidis Christos P, Papantonis Argyris, Gorgoulis Vassilis G
Molecular Carcinogenesis Group, Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, Athens, Greece.
Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Mol Cell Oncol. 2022 Feb 15;9(1):2030158. doi: 10.1080/23723556.2022.2030158. eCollection 2022.
Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.
尽管衰老一直被认为是一种不可逆的细胞停滞状态，但越来越多的证据对这一观点提出了挑战。因此，衰老似乎是阻碍癌症进展的一个不完美障碍，是疾病复发之前的一个阶段。所以，如果重新审视癌症治疗策略以纳入衰老细胞溶解剂，可能会从中受益。
