Wehner A P, Weller R E, Lepel E A
Food Chem Toxicol. 1986 Apr;24(4):329-38. doi: 10.1016/0278-6915(86)90011-6.
The objective of this study was to investigate whether multiple vaginal depositions of neutron-activated talc in the cynomolgus monkey result in the translocation of this material to the uterus and beyond. Within a 45-day period, six monkeys received 30 applications of 125 mg neutron-activated talc, suspended in 0.3 ml physiological saline solution containing 1% carboxymethyl cellulose as a suspending agent. The suspension was deposited in the posterior vaginal fornix of the sedated monkeys. Two days after the final talc application, the animals were anaesthetized. Abdominal lavage was performed and the lavage fluid collected for gamma-ray analysis. Also collected for gamma-ray analysis were the following tissues/organs: ovaries, oviducts, uterus, and vagina with cervix. Six untreated control monkeys underwent the same procedures. The radioisotopes 46Sc, 60Co, 59Fe and 51Cr in the activated talc served as tracers. Only the samples containing vagina and cervix from the dosed monkeys contained varying quantities of talc. This demonstrates that no measurable quantities of talc, deposited by multiple applications in the vaginal fornix of the cynomolgus monkey, translocated to the uterus or beyond.
本研究的目的是调查食蟹猴阴道多次沉积经中子活化的滑石粉是否会导致该物质转移至子宫及其他部位。在45天内，六只猴子接受了30次125毫克经中子活化的滑石粉涂抹，滑石粉悬浮于含有1%羧甲基纤维素作为悬浮剂的0.3毫升生理盐水中。该悬浮液被沉积于麻醉状态猴子的阴道后穹窿。在最后一次涂抹滑石粉两天后，对动物实施麻醉。进行腹腔灌洗并收集灌洗液用于伽马射线分析。还收集了以下组织/器官用于伽马射线分析：卵巢、输卵管、子宫以及带有宫颈的阴道。六只未接受处理的对照猴子接受相同的操作步骤。活化滑石粉中的放射性同位素46Sc、60Co、59Fe和51Cr用作示踪剂。仅来自给药猴子的含有阴道和宫颈的样本含有不同数量的滑石粉。这表明在食蟹猴阴道后穹窿多次涂抹的滑石粉没有可测量数量转移至子宫或其他部位。
