滑石粉从会阴迁移到多个盆腔器官部位。
Migration of Talc From the Perineum to Multiple Pelvic Organ Sites.
机构信息
John J. Godleski, MD, PLLC, Milton, MA.
Electron Microscopy Laboratory, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
出版信息
Am J Clin Pathol. 2019 Oct 7;152(5):590-607. doi: 10.1093/ajcp/aqz080.
OBJECTIVES
Genital talc use is associated with increased risk for ovarian carcinoma in epidemiologic studies. Finding talc in pelvic tissues in women with ovarian carcinoma who have used talc is important in documenting exposure and assessing talc's biologic potential, but tissue-based morphology studies have been rarely reported.
METHODS
We report five patient cases with documented perineal talc use, each of whom had talc (by both polarized light and scanning electron microscopy) in multiple pelvic sites distant from the perineum. Six negative-exposure control patients were also analyzed.
RESULTS
Talc particles were found in exposed patients, typically within two or more of the following locations: pelvic region lymph nodes, cervix, uterine corpus, fallopian tubes, and ovaries.
CONCLUSIONS
Our report adds new insights into the biologic potential of talc and suggests additional anatomic sites that should be closely examined for talc by oncologic surgical pathologists in the setting of perineal talc use.
目的
在流行病学研究中，外阴滑石粉的使用与卵巢癌风险增加有关。在曾使用滑石粉的卵巢癌女性的盆腔组织中发现滑石粉，对于记录接触情况和评估滑石粉的生物学潜能很重要，但基于组织的形态学研究很少报道。
方法
我们报告了 5 例有记录的会阴滑石粉使用的患者病例，每位患者的会阴以外的多个盆腔部位都发现了滑石粉（通过偏光显微镜和扫描电子显微镜）。还分析了 6 例无暴露的对照患者。
结果
在暴露的患者中发现了滑石粉颗粒，通常在以下两个或更多部位：盆腔区域淋巴结、宫颈、子宫体、输卵管和卵巢。
结论
我们的报告增加了滑石粉生物学潜能的新见解，并提示在会阴使用滑石粉的情况下，肿瘤外科病理学家应在更多的解剖部位仔细检查滑石粉。
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