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Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia.利多卡因凝胶与聚维酮碘联合使用以减少局部麻醉手术中的获得性感染。
J Cataract Refract Surg. 2020 Jul;46(7):1047-1050. doi: 10.1097/j.jcrs.0000000000000245.
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Ophthalmic Surg Lasers Imaging. 2012 Mar-Apr;43(2):115-20. doi: 10.3928/15428877-20120119-01. Epub 2012 Jan 26.
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Comparing the in vitro efficacy of chlorhexidine and povidone-iodine in the prevention of post-surgical endophthalmitis.比较洗必泰和聚维酮碘预防术后眼内炎的体外疗效。
J Ophthalmic Inflamm Infect. 2024 May 23;14(1):20. doi: 10.1186/s12348-024-00404-2.
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Infect Drug Resist. 2021 Mar 25;14:1231-1238. doi: 10.2147/IDR.S304675. eCollection 2021.

本文引用的文献

1
Microbial flora and resistance in ophthalmology: a review.眼科中的微生物菌群与耐药性：综述
Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):851-862. doi: 10.1007/s00417-017-3608-y. Epub 2017 Feb 22.
2
Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones.A 群链球菌 M1 蛋白提供了对组蛋白抗菌活性的抗性。
Sci Rep. 2017 Feb 21;7:43039. doi: 10.1038/srep43039.
3
Ocular flora and their antibiotic susceptibility in patients having cataract surgery in Italy.意大利白内障手术患者的眼部菌群及其抗生素敏感性。
J Cataract Refract Surg. 2016 Sep;42(9):1312-1317. doi: 10.1016/j.jcrs.2016.07.022.
4
Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis.微生物群对眼部铜绿假单胞菌诱导性角膜炎抵抗力的影响
PLoS Pathog. 2016 Sep 22;12(9):e1005855. doi: 10.1371/journal.ppat.1005855. eCollection 2016 Sep.
5
Postcataract surgery endophthalmitis after introduction of the ESCRS protocol: a 5-year study.引入欧洲白内障与屈光手术学会（ESCRS）协议后白内障手术后眼内炎的5年研究
Eur J Ophthalmol. 2014 Jul-Aug;24(4):516-9. doi: 10.5301/ejo.5000417. Epub 2013 Dec 16.
6
Endophthalmitis.眼内炎。
Clin Microbiol Infect. 2013 Mar;19(3):227-34. doi: 10.1111/1469-0691.12118.
7
Macular infarction after inadvertent intracameral cefuroxime. inadvertent intracameral cefuroxime 致黄斑区梗死
J Cataract Refract Surg. 2011 Jun;37(6):1168-9. doi: 10.1016/j.jcrs.2011.03.032.
8
Povidone-iodine before lidocaine gel anesthesia achieves surface antisepsis.在利多卡因凝胶麻醉前使用聚维酮碘可实现表面消毒。
Ophthalmic Surg Lasers Imaging. 2011 Jul-Aug;42(4):346-9. doi: 10.3928/15428877-20110210-02. Epub 2011 Feb 17.
9
Ocular toxicity after intracameral injection of very high doses of cefuroxime during cataract surgery.白内障手术中玻璃体内注射超高剂量头孢呋辛后的眼毒性。
J Cataract Refract Surg. 2011 Feb;37(2):271-8. doi: 10.1016/j.jcrs.2010.08.047.
10
Endophthalmitis after intravitreal injections.玻璃体内注射后发生的眼内炎。
Expert Opin Pharmacother. 2009 Sep;10(13):2119-26. doi: 10.1517/14656560903081752.

利多卡因凝胶与聚维酮碘联合使用以减少局部麻醉手术中的获得性感染。

Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topical anesthesia.

作者信息

Xia Julia, Lyons Riley J, Lin Mung Yan, Khalifa Yousuf M, LaRock Christopher N

机构信息

From the Emory University School of Medicine (Xia, Lyons, Lin), Department of Ophthalmology, Emory University School of Medicine (Khalifa), Department of Ophthalmology, Grady Memorial Hospital (Khalifa), Department of Microbiology and Immunology (LaRock), Emory University School of Medicine, Division of Infectious Disease (LaRock), Emory University School of Medicine, Emory Antibiotic Resistance Center (LaRock), Atlanta, Georgia, USA.

出版信息

J Cataract Refract Surg. 2020 Jul;46(7):1047-1050. doi: 10.1097/j.jcrs.0000000000000245.

DOI:10.1097/j.jcrs.0000000000000245
PMID:32427643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7423597/
Abstract

PURPOSE

To test the antiseptic efficacy of povidone-iodine when mixed with topical lidocaine gel.

SETTING

Emory School of Medicine, Atlanta, Georgia, USA.

DESIGN

Experimental study.

METHODS

Staphylococcus epidermidis, Staphylococcus aureus, viridans streptococci (Streptococcus sanguinis), Escherichia coli, and Pseudomonas aeruginosa were grown on blood agar plates with povidone-iodine and/or lidocaine gel. The efficacy of sterilization was quantified by surviving bacterial colony-forming units.

RESULTS

Combination of povidone-iodine and lidocaine gel prevented bacterial growth to levels similar to povidone-iodine alone. Application of lidocaine gel to bacteria before povidone-iodine treatment allowed bacterial growth similar to controls not exposed to povidone-iodine.

CONCLUSIONS

Povidone-iodine must be applied before lidocaine gel for effective antisepsis, but admixture of povidone-iodine with lidocaine gel was also effective and may reduce the risk of endophthalmitis associated with lidocaine gel use. This strategy offers a practice-changing alternative for preoperative prophylaxis in procedures requiring topical anesthesia.

摘要

目的

测试聚维酮碘与外用利多卡因凝胶混合后的抗菌效果。

地点

美国佐治亚州亚特兰大市埃默里大学医学院。

设计

实验研究。

方法

将表皮葡萄球菌、金黄色葡萄球菌、草绿色链球菌（血链球菌）、大肠杆菌和铜绿假单胞菌接种于含有聚维酮碘和/或利多卡因凝胶的血琼脂平板上。通过存活细菌菌落形成单位对杀菌效果进行量化。

结果

聚维酮碘与利多卡因凝胶联合使用可防止细菌生长至与单独使用聚维酮碘相似的水平。在聚维酮碘治疗前将利多卡因凝胶应用于细菌，会使细菌生长情况与未接触聚维酮碘的对照组相似。

结论

为实现有效的消毒，必须在利多卡因凝胶之前应用聚维酮碘，但聚维酮碘与利多卡因凝胶混合使用也有效，且可能降低与使用利多卡因凝胶相关的眼内炎风险。该策略为需要局部麻醉的手术提供了一种改变实践的术前预防替代方法。