Korea Disease Control and Prevention Agency, Cheongju, Korea.
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2022 Mar 7;37(9):e79. doi: 10.3346/jkms.2022.37.e79.
infection is a highly fatal disease resulting from the consumption of raw or undercooked seafood and exposure to seawater containing the organism. It has been a nationally notifiable disease since 2000 in Korea. The aims of this study were to assess the trends in the incidence of infection and its case fatality rate and to determine the epidemiologic characteristics to effectively prevent infection and lower mortality.
We analyzed the incidence trends of infection by year, month, and region in 913 cases reported to the Korea Centers for Disease Control and Prevention (KCDC, currently Korea Disease Control and Prevention Agency) by the National Infectious Disease Surveillance System from 2001 to 2016. We analyzed the number of patients with infection who were under the National Health Insurance Service (NHIS) and whose coastal seawater temperature data were provided by the Korea Oceanographic Data Center of the National Institute of Fisheries Science. Epidemiological investigations were followed up and analyzed for 761 patients from 2003 to 2016. A total of 152 patients who were not followed up were excluded from the analysis. The case fatality rate was analyzed for 325 cases reported to the KCDC from 2011 to 2016.
The mean incidence of infection was 0.12 per 100,000 people, and the highest incidence was reported in September (41.1%) during the study period. The incidence rate per 100,000 people was the highest in Jeonnam (8.23). The number of patients who claimed to the NHIS was the highest in September (105 patients). The average seawater temperature was the highest at 24.1°C in August, and the average seawater temperature from August to October, when many cases occurred, was 22.4°C. The male-to-female ratio was 6:1, and 96.4% of the patients were aged ≥ 40 years. Of the patients, 96.1% had underlying diseases, the most common of which was liver cirrhosis (56.3%). The case fatality rate was 48.9%.
The occurrence of infection showed distinct seasonality, with a large number of cases occurring in the months when the seawater temperature was high; there were also distinct geographical characteristics. The incidence of infection and mortality rates have not decreased for decades, and it is still an important public health problem with a high fatality rate.
感染是一种由食用生的或未煮熟的海鲜以及接触含有该病原体的海水引起的高致命性疾病。自 2000 年以来，韩国已将其列为法定传染病。本研究的目的是评估感染发病率及其病死率的趋势，并确定流行病学特征，以有效预防感染和降低死亡率。
我们分析了 2001 年至 2016 年期间，通过国家传染病监测系统向韩国疾病控制与预防中心（KCDC，现称韩国疾病控制与预防局）报告的 913 例感染病例的发病率趋势，按年份、月份和地区进行分析。我们分析了接受国家健康保险服务（NHIS）的感染患者人数以及韩国海洋科学研究所的韩国海洋数据中心提供的沿海海水温度数据。对 2003 年至 2016 年的 761 例患者进行了流行病学调查和分析。总共排除了 152 例未随访的患者。对 2011 年至 2016 年向 KCDC 报告的 325 例病例进行了病死率分析。
感染的平均发病率为每 10 万人 0.12 例，研究期间发病率最高的月份为 9 月（41.1%）。每 10 万人发病率最高的地区是全罗南道（8.23）。向 NHIS 索赔的患者人数最多的月份是 9 月（105 人）。平均海水温度最高的月份是 8 月，为 24.1°C，而发生大量病例的 8 月至 10 月的平均海水温度为 22.4°C。男女比例为 6:1，96.4%的患者年龄≥40 岁。患者中有 96.1%患有基础疾病，最常见的是肝硬化（56.3%）。病死率为 48.9%。
感染的发生具有明显的季节性，高温月份海水温度发生大量病例；还具有明显的地域特征。感染的发病率和死亡率几十年来没有下降，仍然是一个具有高死亡率的重要公共卫生问题。
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