Emerg Infect Dis. 2022 May;28(5):1050-1052. doi: 10.3201/eid2805.220271. Epub 2022 Mar 8.
To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose vaccination. Cross-variant neutralizing activity was comparable to that after 3-dose vaccination. Shorter intervals between vaccination and breakthrough infection correlated with lower neutralizing titers.
为了确定针对严重急性呼吸综合征冠状病毒 2 原始株和 4 种关注变异株的中和活性，我们检测了 30 名 2 剂疫苗接种后突破性感染患者的血清。跨变异中和活性与 3 剂疫苗接种后相当。疫苗接种和突破性感染之间的间隔时间越短，中和滴度越低。
