Dalton Cardiovascular Research Center and Department of Medical Pharmacology & Physiology, School of Medicine, University of Missouri, USA.
Cell Signal. 2022 May;93:110297. doi: 10.1016/j.cellsig.2022.110297. Epub 2022 Mar 5.
Regulation of protein tyrosine phosphorylation is critical for most, if not all, fundamental cellular processes. However, we still do not fully understand the complex and tissue-specific roles of protein tyrosine phosphatases in the normal heart or in cardiac pathology. This review compares and contrasts the various roles of protein tyrosine phosphatases known to date in the context of cardiac disease and development. In particular, it will be considered how specific protein tyrosine phosphatases control cardiac hypertrophy and cardiomyocyte contractility, how protein tyrosine phosphatases contribute to or ameliorate injury induced by ischaemia / reperfusion or hypoxia / reoxygenation, and how protein tyrosine phosphatases are involved in normal heart development and congenital heart disease. This review delves into the newest developments and current challenges in the field, and highlights knowledge gaps and emerging opportunities for future research.
蛋白质酪氨酸磷酸化的调节对大多数（如果不是全部的话）基本细胞过程至关重要。然而，我们仍然不完全了解蛋白质酪氨酸磷酸酶在正常心脏或心脏病理学中的复杂和组织特异性作用。本综述比较和对比了迄今为止在心脏疾病和发育背景下已知的各种蛋白质酪氨酸磷酸酶的作用。特别是，将考虑特定的蛋白质酪氨酸磷酸酶如何控制心肌肥厚和心肌细胞收缩性，蛋白质酪氨酸磷酸酶如何促进或改善缺血/再灌注或缺氧/复氧引起的损伤，以及蛋白质酪氨酸磷酸酶如何参与正常心脏发育和先天性心脏病。本综述深入探讨了该领域的最新发展和当前挑战，并强调了未来研究的知识空白和新机遇。
