Benka-Coker Megan L, Clark Maggie L, Rajkumar Sarah, Young Bonnie N, Bachand Annette M, Brook Robert D, Nelson Tracy L, Volckens John, Reynolds Stephen J, Wilson Ander, L'Orange Christian, Good Nicholas, Quinn Casey, Koehler Kirsten, Africano Sebastian, Osorto Pinel Anibal B, Diaz-Sanchez David, Neas Lucas, Peel Jennifer L
Department of Health Sciences, Gettysburg College, Gettysburg, PA, USA; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Int J Hyg Environ Health. 2022 Apr;241:113949. doi: 10.1016/j.ijheh.2022.113949. Epub 2022 Mar 5.
Household air pollution from solid fuel combustion was estimated to cause 2.31 million deaths worldwide in 2019; cardiovascular disease is a substantial contributor to the global burden. We evaluated the cross-sectional association between household air pollution (24-h gravimetric kitchen and personal particulate matter (PM) and black carbon (BC)) and C-reactive protein (CRP) measured in dried blood spots among 107 women in rural Honduras using wood-burning traditional or Justa (an engineered combustion chamber) stoves. A suite of 6 additional markers of systemic injury and inflammation were considered in secondary analyses. We adjusted for potential confounders and assessed effect modification of several cardiovascular-disease risk factors. The median (25th, 75th percentiles) 24-h-average personal PM concentration was 115 μg/m (65,154 μg/m) for traditional stove users and 52 μg/m (39, 81 μg/m) for Justa stove users; kitchen PM and BC had similar patterns. Higher concentrations of PM and BC were associated with higher levels of CRP (e.g., a 25% increase in personal PM was associated with a 10.5% increase in CRP [95% CI: 1.2-20.6]). In secondary analyses, results were generally consistent with a null association. Evidence for effect modification between pollutant measures and four different cardiovascular risk factors (e.g., high blood pressure) was inconsistent. These results support the growing evidence linking household air pollution and cardiovascular disease.
据估计，2019年全球因固体燃料燃烧造成的家庭空气污染导致231万人死亡；心血管疾病是全球负担的一个重要因素。我们评估了洪都拉斯农村地区107名使用燃木传统炉灶或Justa（一种工程燃烧室）炉灶的妇女家庭空气污染（24小时重量法测定的厨房和个人颗粒物（PM）以及黑碳（BC））与干血斑中测量的C反应蛋白（CRP）之间的横断面关联。在二次分析中考虑了另外6种全身损伤和炎症标志物。我们对潜在混杂因素进行了调整，并评估了几种心血管疾病风险因素的效应修正。传统炉灶使用者的24小时平均个人PM浓度中位数（第25、75百分位数）为115μg/m（65,154μg/m），Justa炉灶使用者为52μg/m（39,81μg/m）；厨房PM和BC有类似模式。较高浓度的PM和BC与较高水平的CRP相关（例如，个人PM增加25%与CRP增加10.5%相关[95%CI：1.2-20.6]）。在二次分析中，结果总体上与零关联一致。污染物测量与四种不同心血管危险因素（如高血压）之间效应修正的证据不一致。这些结果支持了越来越多的将家庭空气污染与心血管疾病联系起来的证据。
