Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Center for Global Non-Communicable Disease Research and Training, Johns Hopkins University, Baltimore, MD, USA.
Indoor Air. 2021 Sep;31(5):1509-1521. doi: 10.1111/ina.12814. Epub 2021 Mar 22.
Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1β, and TNF-α) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM ), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO ) in a subset of 97 participants. We conducted an exposure-response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM . As expected, kitchen area BC concentrations were positively associated with TNF-α (pro-inflammatory) concentrations and negatively associated with IL-10, an anti-inflammatory marker, controlling for confounders in single- and multi-pollutant models. However, contrary to expectations, kitchen area BC and NO concentrations were negatively associated with IL-1β, a pro-inflammatory marker. No associations were identified for IL-6 or CRP, or for any marker in relation to personal exposures.
家庭燃烧生物质产生的空气污染（HAP）是心肺疾病的主要风险因素；然而，其毒性途径及其与炎症标志物的关系尚不清楚。在秘鲁农村的 180 名成年女性中，我们使用一项随机试验的基线测量结果，检验了生物质 HAP 与血液中炎症标志物之间的横断面暴露反应关系。我们通过干血斑测量了炎症标志物（CRP、IL-6、IL-10、IL-1β 和 TNF-α），并在 97 名参与者的亚组中测量了 48 小时厨房区域浓度和个人暴露于细颗粒物（PM ）、黑碳（BC）和一氧化碳（CO）以及 48 小时厨房浓度的二氧化氮（NO ）。我们在 HAP 水平五分位数和炎症标志物之间进行了暴露反应分析。炎症标志物与厨房区域 BC 浓度的相关性强于 PM 。如预期的那样，厨房区域 BC 浓度与促炎标志物 TNF-α浓度呈正相关，与抗炎标志物 IL-10 浓度呈负相关，在单污染物和多污染物模型中控制了混杂因素。然而，与预期相反，厨房区域 BC 和 NO 浓度与促炎标志物 IL-1β 呈负相关。在个人暴露与任何标志物之间都没有发现 IL-6 或 CRP 或任何标志物的关联。
