College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Lab Carbon Based Functional Materials and Devices, Soochow University, Suzhou, 215123, Jiangsu, China.
Angew Chem Int Ed Engl. 2021 Jul 26;60(31):16763-16776. doi: 10.1002/anie.202102574. Epub 2021 Mar 23.
Metal-organic frameworks (MOFs) hold great promise for biomedical applications owing to their unique properties. The porous structures make MOFs excellent candidates for the delivery of different drugs; the flexibility in choosing metal ions and organic ligands makes it feasible to prepare MOFs with intrinsic antitumor activities and further devise MOF-drug synergistic systems; many other types of antitumor agents could also be developed using MOFs as the precursors/templates. Thus, the past two decades have witnessed the great development of MOF-based drugs, especially in the antitumor field. This Minireview mainly focuses on the design and applications of MOF-based antitumor agents. Four aspects covering the whole field are introduced: MOFs as carriers, MOFs as antitumor agents, MOF-drug synergistic systems, and MOF-derived antitumor agents. The challenges and opportunities of MOFs for clinical antitumor applications are also discussed.
金属-有机骨架（MOFs）由于其独特的性质，在生物医学应用中具有很大的应用前景。多孔结构使 MOFs 成为递送不同药物的优秀候选物；选择金属离子和有机配体的灵活性使得制备具有内在抗肿瘤活性的 MOFs 并进一步设计 MOF-药物协同系统成为可能；还可以使用 MOFs 作为前体/模板来开发许多其他类型的抗肿瘤药物。因此，在过去的二十年中，基于 MOF 的药物取得了巨大的发展，特别是在抗肿瘤领域。这篇综述主要关注基于 MOF 的抗肿瘤药物的设计和应用。涵盖整个领域的四个方面进行了介绍：MOFs 作为载体、MOFs 作为抗肿瘤药物、MOF-药物协同系统和 MOF 衍生的抗肿瘤药物。还讨论了 MOFs 用于临床抗肿瘤应用的挑战和机遇。
