Pediatric Research Unit, Department of Pediatrics, Holbaek University Hospital, 4300, Holbaek, Denmark.
Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Sci Rep. 2022 Mar 8;12(1):4040. doi: 10.1038/s41598-022-07944-4.
To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.
为了提供关于 COVID-19 成年患者中表面活性剂水平的新数据，我们在插管后不到 72 小时内收集了支气管肺泡灌洗液，并使用傅里叶变换红外光谱法测量二棕榈酰磷脂酰胆碱（DPPC）的水平。共纳入 11 例中重度急性呼吸窘迫综合征（ARDS）的 COVID-19 患者和 15 例健康对照者。ARDS 患者的 DPPC 水平低于健康对照组。此外，主成分分析能够将患者群体分为可区分的亚组。我们的研究结果表明 COVID-19 患者的肺表面活性物质水平明显受损，这证明了进一步研究和外源性表面活性剂的临床试验是合理的。
