Dao Thi Loi, Hoang Van Thuan, Colson Philippe, Million Matthieu, Gautret Philippe
Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.
IHU-Méditerranée Infection, Marseille, France.
J Clin Virol Plus. 2021 Sep;1(3):100036. doi: 10.1016/j.jcvp.2021.100036. Epub 2021 Aug 9.
We conducted this meta-analysis to determine the proportion of co-infection with influenza viruses in SARS-CoV-2 positive patients and to investigate the severity of COVID-19 in these patients. We included studies with SARS-CoV-2 infection confirmed by qRT-PCR and influenza virus infection (A and/or B) by nucleic acid tests. The proportion of co-infection was compared between children and adults, and between critically ill or deceased patients compared to overall patients. Fifty-four articles were included. The overall proportion of co-infection was 0.7%, 95%CI = [0.4 - 1.3]. Most influenza co-infections were due to the influenza A virus (74.4%). The proportion of co-infection with influenza viruses among children (3.2%, 95% CI = [0.9 - 10.9]) was significantly higher than that in adult patients (0.3%, 95% CI = [0.1 - 1.2]), p-value <0.01. The proportion of co-infection with influenza viruses among critically ill patients tended to be higher than that in overall patients (2.2%, 95% CI = [0.3 - 22.4] versus 0.6%, 95% CI = [0.3 - 1.2], respectively, p-value = 0.22). Screening for pathogens in co-infection, particularly influenza viruses in patients infected with SARS-CoV-2, is necessary. This warrants close surveillance and investigation of the co-incidences and interactions of SARS-CoV-2 and other respiratory viruses, which is facilitated by the expansion of syndromic diagnosis approaches through the use of multiplex PCR assays.
我们进行了这项荟萃分析，以确定严重急性呼吸综合征冠状病毒2（SARS-CoV-2）阳性患者中流感病毒合并感染的比例，并调查这些患者中冠状病毒病（COVID-19）的严重程度。我们纳入了通过定量逆转录聚合酶链反应（qRT-PCR）确诊SARS-CoV-2感染以及通过核酸检测确诊流感病毒（甲型和/或乙型）感染的研究。比较了儿童和成人之间以及重症或死亡患者与所有患者之间合并感染的比例。共纳入54篇文章。合并感染的总体比例为0.7%，95%置信区间（CI）=[0.4 - 1.3]。大多数流感合并感染是由甲型流感病毒引起的（74.4%）。儿童中流感病毒合并感染的比例（3.2%，95% CI =[0.9 - 10.9]）显著高于成年患者（0.3%，95% CI =[0.1 - 1.2]），p值<0.01。重症患者中流感病毒合并感染的比例往往高于所有患者（分别为2.2%，95% CI =[0.3 - 22.4]和0.6%，95% CI =[0.3 - 1.2]），p值=0.22。对合并感染中的病原体进行筛查，特别是对感染SARS-CoV-2的患者中的流感病毒进行筛查是必要的。这需要对SARS-CoV-2与其他呼吸道病毒的共现和相互作用进行密切监测和调查，通过使用多重聚合酶链反应（PCR）检测扩展症状诊断方法有助于实现这一点。
