KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Leuven, Belgium.
Curr Protoc. 2022 Mar;2(3):e376. doi: 10.1002/cpz1.376.
Nucleos(t)ide chemistry has been the subject of intense research, mainly because of the promising antiviral and antitumoral activity associated with this compound class. Numerous analogs have been synthesized over the past decades, yielding a number of derivatives that have reached the status of marketed drugs. Herein, an overview of the nucleos(t)ide analogs that have received marketing approval is given. The review is divided into several sections, including antiviral and antitumoral nucleoside analogs as well as nucleoside analogs that have received marketing approval in other therapeutic areas. © 2022 Wiley Periodicals LLC.
核苷（酸）化学一直是研究的热点，主要是因为该类化合物具有有前景的抗病毒和抗肿瘤活性。在过去几十年中，已经合成了许多类似物，产生了许多已成为市售药物的衍生物。本文概述了已获得上市批准的核苷（酸）类似物。综述分为几个部分，包括抗病毒和抗肿瘤核苷类似物以及已在其他治疗领域获得上市批准的核苷类似物。© 2022 Wiley Periodicals LLC.
