Department of Internal Medicine VI: Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany.
Z Gastroenterol. 2022 Mar;60(3):299-309. doi: 10.1055/a-1708-0277. Epub 2022 Mar 9.
A proportion of irritable bowel syndrome (IBS) affected patients does not fulfil Rome criteria despite considerable impairment similarly to that in patients with organic gastrointestinal diseases.This investigation aims to examine differences regarding Mental (MQoL), Physical Quality of Life (PQoL), and sleep between IBS according to Rome III (IBS Rome), clinically defined IBS, inflammatory bowel diseases (IBD), and non-IBS/non-IBD individuals.
Data from SHIP-Trend (Study of Health in Pomerania, 2008-2012), a population-based cohort study in Germany, were used.
Response was 50.1% ( = 4420). Prevalence was 3.5% for IBS Rome (95% confidence interval (CI): 3.0 - 4.1%, = 148), 0.6% for clinically defined IBS (CI: 0.4 - 0.9%, = 27), and 0.8% for IBD (CI: 0.6 - 1.1%, = 34). Individuals with IBS Rome (4.54 (CI: -5.92; -3.17)) and clinically defined IBS (4.69 (CI: -7.82; -1.56)) had lower scores for MQoL compared to the non-IBS/non-IBD group. PQoL scores were lowered in IBS Rome (6.39 (CI: -7.89; -4.88)) and IBD (5.37 (CI: -8.51; -2.22)), but not in clinically defined IBS compared to the non-IBS/non-IBD group. IBS Rome was the only gastroenterological condition with higher odds of sleeping problems (odds ratio (OR) "falling asleep": 1.74; CI: 1.29; 2.36; OR "remaining asleep": 1.73; CI: 1.26; 2.38).
IBS Rome is associated with reduced MQoL, PQoL, and sleep problems. Clinically defined IBS is associated only with reduced MQoL. Heterogeneity within IBS affected patients should be considered in clinical routine and screening for daily life impairment should be performed.
尽管有相当大的损害，类似于器质性胃肠道疾病患者，一部分肠易激综合征（IBS）患者不符合罗马标准。本研究旨在检查根据罗马 III 标准（IBS-Rome）诊断的 IBS、临床定义的 IBS、炎症性肠病（IBD）和非 IBS/非 IBD 个体之间的精神健康（MQoL）、身体生活质量（PQoL）和睡眠差异。
使用德国基于人群的队列研究 SHIP-Trend（2008-2012 年波美拉尼亚健康研究）的数据。
应答率为 50.1%（=4420）。IBS-Rome 的患病率为 3.5%（95%置信区间（CI）：3.0-4.1%，=148），临床定义的 IBS 为 0.6%（CI：0.4-0.9%，=27），IBD 为 0.8%（CI：0.6-1.1%，=34）。与非 IBS/非 IBD 组相比，IBS-Rome（4.54（CI：-5.92；-3.17））和临床定义的 IBS（4.69（CI：-7.82；-1.56））患者的 MQoL 评分较低。IBS-Rome（6.39（CI：-7.89；-4.88））和 IBD（5.37（CI：-8.51；-2.22））的 PQoL 评分降低，但与非 IBS/非 IBD 组相比，临床定义的 IBS 没有降低。IBS-Rome 是唯一一种与睡眠问题相关的胃肠道疾病（入睡的可能性比（OR）为 1.74（CI：1.29；2.36）；保持入睡的可能性（OR）为 1.73（CI：1.26；2.38）。
IBS-Rome 与 MQoL、PQoL 和睡眠问题降低有关。临床定义的 IBS 仅与 MQoL 降低有关。在临床常规中应考虑到 IBS 受影响患者的异质性，并应进行日常生活损害筛查。
