心脏异种移植的未来。
The future of cardiac xenotransplantation.
机构信息
Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Nat Rev Cardiol. 2022 May;19(5):281-282. doi: 10.1038/s41569-022-00684-y.
Abstract
Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial clinical trials are expected to explore compassionate use as destination therapy in carefully selected adult patients and as a bridge to heart allotransplantation in infant patients with complex congenital heart disease.
摘要
在这篇临床展望文章中，我们反思了首例基因工程猪到人类心脏移植，讨论了心脏异种移植的可能未来。预计初步临床试验将探索在精心挑选的成年患者中作为同情使用的终点治疗，以及作为患有复杂先天性心脏病的婴儿患者心脏同种移植的桥梁。
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The future of cardiac xenotransplantation.心脏异种移植的未来。
Nat Rev Cardiol. 2022 May;19(5):281-282. doi: 10.1038/s41569-022-00684-y.
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本文引用的文献
1
The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.异种移植心脏的生长可以通过生长激素受体敲除猪供体来减少。
J Thorac Cardiovasc Surg. 2023 Feb;165(2):e69-e81. doi: 10.1016/j.jtcvs.2021.07.051. Epub 2021 Sep 4.
2
Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout).旧世界猴不太适合作为测试缺乏三种碳水化合物抗原（三重敲除）的猪器官的移植模型。
Sci Rep. 2020 Jun 17;10(1):9771. doi: 10.1038/s41598-020-66311-3.
3
Pig-to-human heart transplantation: Who goes first?猪心移植到人：谁先受益？
Am J Transplant. 2020 Oct;20(10):2669-2674. doi: 10.1111/ajt.15916. Epub 2020 May 25.
4
Justification of specific genetic modifications in pigs for clinical organ xenotransplantation.为临床器官异种移植对猪进行特定基因修饰的理由。
Xenotransplantation. 2019 Jul;26(4):e12516. doi: 10.1111/xen.12516. Epub 2019 Apr 15.
5
Consistent success in life-supporting porcine cardiac xenotransplantation.在支持猪心异种移植方面取得持续成功。
Nature. 2018 Dec;564(7736):430-433. doi: 10.1038/s41586-018-0765-z. Epub 2018 Dec 5.
6
The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?新生儿心脏异种移植的理由：现在是重新考虑针对左心发育不全综合征进行异种移植的时候了吗？
Pediatr Cardiol. 2019 Feb;40(2):437-444. doi: 10.1007/s00246-018-1998-1. Epub 2018 Oct 9.
7
Does human leukocyte antigens sensitization matter for xenotransplantation?人类白细胞抗原致敏对异种移植有影响吗？
Xenotransplantation. 2018 May;25(3):e12411. doi: 10.1111/xen.12411.
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Neonatal heart transplantation.新生儿心脏移植
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