Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nat Rev Cardiol. 2022 May;19(5):281-282. doi: 10.1038/s41569-022-00684-y.
Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial clinical trials are expected to explore compassionate use as destination therapy in carefully selected adult patients and as a bridge to heart allotransplantation in infant patients with complex congenital heart disease.
在这篇临床展望文章中，我们反思了首例基因工程猪到人类心脏移植，讨论了心脏异种移植的可能未来。预计初步临床试验将探索在精心挑选的成年患者中作为同情使用的终点治疗，以及作为患有复杂先天性心脏病的婴儿患者心脏同种移植的桥梁。
