Mu Ronghua, Qin Xiaoyan, Guo Zixuan, Meng Zhuoni, Liu Fuzhen, Zhuang Zeyu, Zheng Wei, Li Xin, Yang Peng, Feng Yuling, Jiang Yanchun, Zhu Xiqi
Graduate School of Guilin Medical University, Guilin, 541004, People's Republic of China.
Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, 541004, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Mar 3;18:499-512. doi: 10.2147/NDT.S352651. eCollection 2022.
To study the variation tendency of cerebral small vessel disease (CSVD) imaging markers and total burden with aging and to research the relationship between aging, CSVD markers and cognitive function.
Participants in local urban communities were recruited for neuropsychological and magnetic resonance imaging assessments. Montreal Cognitive Assessment (MoCA), Mini-mental State Examination (MMSE), Number Connection Test A (NCT-A) and Digital Symbol Test (DST) were adopted as neuropsychological scale. Age was stratified at 5-year intervals, and the variation tendency of imaging markers and variables of neuropsychological scales in different age groups was studied. We further studied the relationship between aging, image markers and neuropsychological scales by multi-linear regression.
Finally, a total of 401 stroke-free participants (age, 54.83±7.74y; 45.9% were male) were included in the present analysis. With the increase of age, the incidence of imaging markers of CSVD were increased with aging except cerebral microbleeds. The performance results of NCT-A and DST were significant difference in 6 age groups ( < 0.001). In addition, linear decline of the neuropsychological function reflected by NCT-A and DST variables was observed. Linear regression found that age was an independent factor affecting the neuropsychological function reflected by NCT-A and DST variables, and the standard correction coefficients among different age groups increased gradually with age. In addition, brain atrophy is an independent factor affecting neuropsychological variables (odds ratio: -2.929, 95% CI: [-5.094 to -0.765]). There was no correlation between the number of neuroimaging markers and neuropsychological variables after full adjustment.
There are many CVSD markers even in younger people, the incidence rate and CVSD marker numbers increase with age. Aging and CSVD may eventually affect cognitive function through brain atrophy.
研究脑小血管病（CSVD）影像学标志物及总负荷随年龄的变化趋势，并探讨年龄、CSVD标志物与认知功能之间的关系。
招募当地城市社区的参与者进行神经心理学和磁共振成像评估。采用蒙特利尔认知评估量表（MoCA）、简易精神状态检查表（MMSE）、数字连接试验A（NCT-A）和数字符号试验（DST）作为神经心理学量表。按5岁间隔对年龄进行分层，研究不同年龄组影像学标志物及神经心理学量表变量的变化趋势。通过多元线性回归进一步研究年龄、影像标志物与神经心理学量表之间的关系。
最终，本分析纳入了401名无卒中参与者（年龄54.83±7.74岁；男性占45.9%）。随着年龄增长，除脑微出血外，CSVD影像学标志物的发生率随年龄增加而升高。NCT-A和DST在6个年龄组的表现结果存在显著差异（<0.001）。此外，观察到NCT-A和DST变量所反映的神经心理功能呈线性下降。线性回归发现，年龄是影响NCT-A和DST变量所反映的神经心理功能的独立因素，不同年龄组的标准校正系数随年龄逐渐增加。此外，脑萎缩是影响神经心理变量的独立因素（比值比：-2.929，95%置信区间：[-5.094至-0.765]）。完全调整后，神经影像学标志物数量与神经心理变量之间无相关性。
即使在年轻人中也存在多种CSVD标志物，其发生率和CSVD标志物数量随年龄增加而增加。衰老和CSVD最终可能通过脑萎缩影响认知功能。
