Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Aging (Albany NY). 2021 Feb 1;13(7):9510-9521. doi: 10.18632/aging.202438.
We conducted a cross-sectional study to characterize the relationship between total and modified small vessel disease (SVD) score with vascular cognitive impairment (VCI). Patients (n = 157) between the ages of 50 and 85 years old who had suffered their first lacunar infarction were analyzed prospectively. Brain magnetic resonance imaging was performed to identify SVD manifestations, which were used to calculate total or modified SVD scores. Neuropsychological assessments measured cognitive function. Spearman correlation analysis demonstrated that the total and modified SVD scores were associated with overall cognition as well as with function in the executive and visuospatial domains. The associations remained significant in linear regression after adjusting for age, sex, education and vascular risk factors. Binary logistic regression and chi-squared trend tests revealed that VCI risk increased significantly with SVD burden based on the modified SVD score. Subsequent chi-squared testing demonstrated that the VCI rate was significantly higher in patients with a modified SVD score of 5-6 than in patients without any SVD burden. Our results suggest that both the total and modified SVD scores show a negative association with cognitive function, but the modified SVD score may be better at identifying patients at high VCI risk.
我们进行了一项横断面研究，以描述总小血管疾病（SVD）评分和改良小血管疾病评分与血管性认知障碍（VCI）之间的关系。前瞻性分析了年龄在 50 至 85 岁之间首次发生腔隙性梗死的 157 例患者。进行脑磁共振成像以识别 SVD 表现，并用于计算总 SVD 评分或改良 SVD 评分。神经心理学评估测量认知功能。Spearman 相关分析表明，总 SVD 评分和改良 SVD 评分与整体认知功能以及执行和视空间领域的功能有关。在调整年龄、性别、教育和血管危险因素后，线性回归分析仍显示出显著相关性。二元逻辑回归和卡方趋势检验显示，基于改良 SVD 评分，SVD 负担与 VCI 风险显著增加。进一步的卡方检验表明，改良 SVD 评分为 5-6 的患者 VCI 发生率显著高于无 SVD 负担的患者。我们的研究结果表明，总 SVD 评分和改良 SVD 评分均与认知功能呈负相关，但改良 SVD 评分可能更能识别高 VCI 风险患者。
