Chen Yuhua, Long Tianlin, Xu Quanhua, Zhang Chi
Department of Central Laboratory, Xi'an Peihua University, Xi'an, China.
Department of Neurosurgery, Bijie Traditional Chinese Medicine Hospital, Bijie, China.
Front Pharmacol. 2022 Feb 21;12:817364. doi: 10.3389/fphar.2021.817364. eCollection 2021.
Stroke is a major cause of long-term disability and death, but the clinical therapeutic strategy for stroke is limited and more research must be conducted to explore the possible avenues for stroke treatment and recovery. Since ferroptosis is defined, its role in the body has become the focus of attention and discussion, including in stroke. In this work, we aim to systematically discuss the "ferroptosis in stroke" research by bibliometric analysis. Documents were retrieved from the Web of Science Core Collection database on October 30, 2021. Statistical analysis and visualization analysis were conducted by the VOSviewer 1.6.15. Ninety-nine documents were identified for bibliometric analysis. Research on "ferroptosis in stroke" has been rapidly developing and has remained the focus of many scholars and organizations in the last few years, but the Chinese groups in this field still lacked collaboration with others. Documents and citation analysis suggested that Rajiv R. Ratan and Brent R. Stockwell are active researchers, and the research by Qingzhang Tuo, Ishraq Alim, and Qian Li are more important drivers in the development of the field. Keywords associated with lipid peroxidation, ferroptosis, iron, oxidative stress, and cell death had high frequency, but apoptosis, necroptosis, pyroptosis, and autophagy had scant research, and there may be more research ideas in the future by scholars. Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic "ferroptosis in stroke", to produce more exciting results and provide new insights into the bottleneck of stroke treatment.
中风是导致长期残疾和死亡的主要原因，但中风的临床治疗策略有限，必须开展更多研究以探索中风治疗和康复的可能途径。自铁死亡被定义以来，其在体内的作用已成为关注和讨论的焦点，包括在中风领域。在这项工作中，我们旨在通过文献计量分析系统地讨论“中风中的铁死亡”研究。于2021年10月30日从Web of Science核心合集数据库中检索文献。使用VOSviewer 1.6.15进行统计分析和可视化分析。共识别出99篇文献用于文献计量分析。“中风中的铁死亡”研究发展迅速，在过去几年一直是众多学者和机构关注的焦点，但该领域的中国研究团队仍缺乏与其他团队的合作。文献和引文分析表明，拉吉夫·R·拉坦和布伦特·R·斯托克韦尔是活跃的研究人员，而拓庆樟、伊什拉克·阿里姆和李谦的研究是该领域发展的更重要推动因素。与脂质过氧化、铁死亡、铁、氧化应激和细胞死亡相关的关键词出现频率较高，但细胞凋亡、坏死性凋亡、炎性小体介导的细胞焦亡和自噬的研究较少，未来学者可能会有更多研究思路。进一步探索铁死亡与其他程序性细胞死亡之间的相互作用机制，可能会改善中风的临床应用和治疗效果。学者们也将继续关注并对“中风中的铁死亡”这一热门话题感兴趣，以产生更多令人兴奋的成果，并为中风治疗的瓶颈提供新的见解。
