Chase Kevin, Watkins Maren, Safavi-Hemami Helena, Olivera Baldomero M
School of Biological Sciences, University of Utah, Salt Lake City, UT, United States.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Front Mol Biosci. 2022 Feb 21;9:784419. doi: 10.3389/fmolb.2022.784419. eCollection 2022.
The venomous marine snails are conventionally divided into three groups, the cone snails (family Conidae), the auger snails (family Terebridae) and the turrids (formerly all assigned to a single family, Turridae). In this study, a library of venom peptides from species conventionally assigned to the genus was correlated to a phylogenetic analysis. Nucleotide sequences of multiple genes from transcriptomes were used to assess the phylogenetic relationships across a diverse set of species. The resulting tree shows that as conventionally defined, the conoidean genus , is polyphyletic. We describe a new genus, , that comprises the outlier species. In addition to morphological distinctions, molecular data reveal that this group is divergent from . The correlation between phylogenetic information and a family of peptide sequences was used to highlight those peptides mostly likely to be unique and intimately associated with biological diversity. The plethora of peptide sequences available requires two prioritization decisions: which subset of peptides to initially characterize, and after these are characterized, which to comprehensively investigate for potential biomedical applications such as drug developments. urn:lsid:zoobank.org; pub: 60D46561-28F0-4C39-BAC4-66DC8B4EAEA4.
芋螺（芋螺科）、钻螺（钻螺科）和塔螺（以前都归为塔螺科）。在本研究中，一个来自传统上归为某属物种的毒液肽文库与系统发育分析相关联。利用转录组中多个基因的核苷酸序列来评估一系列不同物种间的系统发育关系。所得的树状图表明，按照传统定义，芋螺超科的某属是多系的。我们描述了一个新属，它包含那些异常物种。除了形态学差异外，分子数据表明这一组与某属不同。系统发育信息与一个肽序列家族之间的关联被用于突出那些最有可能是独特的且与生物多样性密切相关的肽。大量可用的肽序列需要做出两个优先级决策：最初表征哪些肽子集，以及在这些肽被表征后，哪些肽要进行全面研究以用于潜在的生物医学应用，如药物开发。urn:lsid:zoobank.org; pub: 60D46561-28F0-4C39-BAC4-66DC8B4EAEA4.
