Gunning J E
Surg Gynecol Obstet. 1986 Aug;163(2):156-62.
The efficacy and safety of piperacillin were compared with those of clindamycin plus gentamicin in 74 women with obstetric or gynecologic infections (such as endometritis, salpingitis and septic abortion). Thirty-five of the patients in the group treated with piperacillin and 33 of the patients in the group treated with clindamycin plus gentamicin were clinically cured. Clinical failure occurred in two patients in the group treated with piperacillin (salpingitis in one and endometritis in the other patient) and relapse of salpingitis occurred in one. Three patients who were given clindamycin plus gentamicin (all with salpingitis) did not respond to therapy. The most frequently isolated organisms were Neisseria gonorrhea and Bacteroides species. Adverse clinical experiences and the results of laboratory tests were fewer in the group treated with piperacillin than in the patients who received the combination regimen; in neither instance was treatment discontinued because of these effects. Thus, piperacillin was as safe and effective as a combination of clindamycin plus gentamicin.
对74例患有产科或妇科感染（如子宫内膜炎、输卵管炎和感染性流产）的女性患者，比较了哌拉西林与克林霉素加庆大霉素的疗效和安全性。接受哌拉西林治疗组的35例患者和接受克林霉素加庆大霉素治疗组的33例患者临床治愈。接受哌拉西林治疗组有2例患者临床治疗失败（1例为输卵管炎，另1例为子宫内膜炎），1例输卵管炎复发。接受克林霉素加庆大霉素治疗的3例患者（均为输卵管炎）治疗无效。最常分离出的病原体是淋病奈瑟菌和拟杆菌属。接受哌拉西林治疗组的不良临床经验和实验室检查结果比接受联合治疗方案的患者少；在这两种情况下，均未因这些影响而停药。因此，哌拉西林与克林霉素加庆大霉素联合用药一样安全有效。
