Thadepalli H, Mathai D, Scotti R, Bansal M B, Savage E
Department of Medicine, Charles R. Drew University of Medicine and Science, Martin Luther King Jr. General Hospital, Los Angeles, California.
Obstet Gynecol. 1991 Oct;78(4):696-702.
This prospective, randomized controlled study compared the efficacy and safety of ciprofloxacin alone versus a conventional two-drug regimen, clindamycin with gentamicin. The study group included 71 patients hospitalized for pelvic infections such as acute (N = 33) and chronic (N = 8) salpingitis, tubo-ovarian abscesses (N = 11), endometritis (N = 9), septic abortion (N = 3), and other categories (N = 7). Twenty-two of 35 patients on ciprofloxacin and 20 of 36 on clindamycin plus gentamicin had culturable pathogens: gonococci in 28, anaerobes in six, chlamydia in four, and associated pathogens in 19. Complete clinical and bacteriologic cure was achieved in 21 of 22 (95%) in the ciprofloxacin group and 19 of 20 (95%) in the clindamycin plus gentamicin group. The mean duration of intravenous/oral ciprofloxacin therapy was 3.7/7.2 days, and it was 3/6.6 days for clindamycin plus gentamicin. Ciprofloxacin, a new quinolone, appears to be safe as a single-drug therapy and was as effective as the combination of clindamycin plus gentamicin for the treatment of severe pelvic infections requiring hospitalization.
这项前瞻性随机对照研究比较了环丙沙星单药疗法与传统两药联合疗法（克林霉素加庆大霉素）的疗效和安全性。研究组包括71例因盆腔感染住院的患者，如急性（N = 33）和慢性（N = 8）输卵管炎、输卵管卵巢脓肿（N = 11）、子宫内膜炎（N = 9）、感染性流产（N = 3）以及其他类型（N = 7）。35例接受环丙沙星治疗的患者中有22例以及36例接受克林霉素加庆大霉素治疗的患者中有20例培养出了可培养病原体：28例为淋球菌，6例为厌氧菌，4例为衣原体，19例为相关病原体。环丙沙星组22例中的21例（95%）以及克林霉素加庆大霉素组20例中的19例（95%）实现了完全临床和细菌学治愈。环丙沙星静脉/口服治疗的平均疗程为3.7/7.2天，克林霉素加庆大霉素为3/6.6天。新型喹诺酮类药物环丙沙星作为单药疗法似乎是安全的，并且在治疗需要住院的严重盆腔感染方面与克林霉素加庆大霉素联合疗法效果相当。
