Bao Yueyue, Muñoz Anna Igual, Olsson Claes-Olof A, Jolles Brigitte M, Mischler Stefano
École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Swiss BioMotion Lab, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), CH-1011 Lausanne, Switzerland.
Materials (Basel). 2022 Feb 25;15(5):1726. doi: 10.3390/ma15051726.
In this study, we report results of the interaction of titanium (Ti) with human synovial fluids. A wide palette of electrochemical techniques was used, including open circuit potential, potentiodynamic methods, and electrochemical impedance. After the electrochemical testing, selected surfaces were analyzed using Auger Electron Spectroscopy to provide laterally resolved information on surface chemistry. For comparison purposes, similar tests were conducted in a series of simulated body fluids. This study shows that compared to the tested simulated body fluids, synovial liquids show a large patient variability up to one order of magnitude for some crucial electrochemical parameters such as corrosion current density. The electrochemical behavior of Ti exposed to human synovial fluids seems to be controlled by the interaction with organic molecules rather than with reactive oxygen species.
在本研究中，我们报告了钛（Ti）与人体滑液相互作用的结果。我们使用了多种电化学技术，包括开路电位、动电位方法和电化学阻抗。电化学测试后，使用俄歇电子能谱对选定表面进行分析，以提供有关表面化学的横向分辨信息。为了进行比较，在一系列模拟体液中进行了类似测试。这项研究表明，与测试的模拟体液相比，滑液在一些关键电化学参数（如腐蚀电流密度）上显示出高达一个数量级的较大患者变异性。暴露于人体滑液中的Ti的电化学行为似乎受与有机分子而非活性氧的相互作用控制。
