Igual-Munoz Anna, Genilloud Jean-Ludovic, Jolles Brigitte M, Mischler Stefano
Tribology and Interfacial Chemistry Group, Institut des Matériaux, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Swiss BioMotion Laboratory, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), CH-1011 Lausanne, Switzerland.
Bioengineering (Basel). 2023 Jun 22;10(7):749. doi: 10.3390/bioengineering10070749.
Sterilization is a prerequisite for biomedical devices before contacting the human body. It guarantees the lack of infection by eliminating microorganisms (i.e., bacteria, spores and fungi). It constitutes the last fabrication process of a biomedical device. The aim of this paper is to understand the effect of different sterilization methods (ethanol-EtOH, autoclave-AC, autoclave + ultraviolet radiation-ACUV and gamma irradiation-G) on the surface chemistry and electrochemical reactivity (with special attention on the kinetics of the oxygen reduction reaction) of CoCrMo and titanium biomedical alloys used as prosthetic materials. To do that, electrochemical measurements (open circuit potential, polarization resistance, cathodic potentiodynamic polarization and electrochemical impedance spectroscopy) and surface analyses (Auger Electron Spectroscopy) of the sterilized surfaces were carried out. The obtained results show that the effect of sterilization on the corrosion behavior of biomedical alloys is material-dependent: for CoCrMo alloys, autoclave treatment increases the thickness and the chromium content of the passive film increasing its corrosion resistance compared to simple sterilization in EtOH, while in titanium and its alloys, autoclave and UV-light accelerates its corrosion rate by accelerating the kinetics of oxygen reduction.
灭菌是生物医学设备接触人体之前的一个先决条件。它通过消除微生物（即细菌、孢子和真菌）来确保无感染风险。它是生物医学设备制造的最后一道工序。本文的目的是了解不同灭菌方法（乙醇-EtOH、高压灭菌-AC、高压灭菌+紫外线辐射-ACUV和伽马辐射-G）对用作假体材料的CoCrMo和钛生物医学合金的表面化学和电化学反应性（特别关注氧还原反应动力学）的影响。为此，对灭菌后的表面进行了电化学测量（开路电位、极化电阻、阴极动电位极化和电化学阻抗谱）以及表面分析（俄歇电子能谱）。所得结果表明，灭菌对生物医学合金腐蚀行为的影响取决于材料：对于CoCrMo合金，与在EtOH中简单灭菌相比，高压灭菌处理增加了钝化膜的厚度和铬含量，从而提高了其耐腐蚀性；而对于钛及其合金，高压灭菌和紫外线会通过加速氧还原动力学来加快其腐蚀速率。
