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无瘢痕胎儿愈合。治疗意义。

Scarless fetal healing. Therapeutic implications.

作者信息

Adzick N S, Longaker M T

机构信息

Fetal Treatment Program, University of California, San Francisco 94143-0570.

出版信息

Ann Surg. 1992 Jan;215(1):3-7. doi: 10.1097/00000658-199201000-00004.

DOI:10.1097/00000658-199201000-00004
PMID:1731647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1242363/
Abstract

The purpose of this report is to call attention to the fetal wound healing process as a blueprint for ideal tissue repair. Wound healing in the fetus is fundamentally different from healing in the adult. Fetal tissue repair occurs rapidly and in the absence of scar formation. Because scarring and fibrosis dominate some diseases in every area of medicine, an understanding of fetal wound healing should help develop therapeutic strategies to avert the devastating consequences of excessive scar formation.

摘要

本报告的目的是提请关注胎儿伤口愈合过程,将其作为理想组织修复的蓝本。胎儿的伤口愈合与成人的愈合有着根本的不同。胎儿组织修复迅速且不会形成瘢痕。由于瘢痕形成和纤维化在医学各个领域的一些疾病中占主导地位,了解胎儿伤口愈合应有助于制定治疗策略,以避免过度瘢痕形成带来的毁灭性后果。

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1
Scarless fetal healing. Therapeutic implications.无瘢痕胎儿愈合。治疗意义。
Ann Surg. 1992 Jan;215(1):3-7. doi: 10.1097/00000658-199201000-00004.
2
Scar wars: implications of fetal wound healing for the pediatric burn patient.瘢痕之战:胎儿伤口愈合对小儿烧伤患者的影响
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Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair.细胞、基质、生长因子与外科医生。胎儿无瘢痕伤口修复的生物学机制。
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Hyaluronan induces scarless repair in mouse limb organ culture.透明质酸在小鼠肢体器官培养中诱导无瘢痕修复。
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本文引用的文献

1
Inflammation in the foetal and neonatal rat: the local reactions to skin burns.胎鼠和新生鼠的炎症:皮肤烧伤的局部反应。
J Pathol Bacteriol. 1960 Jul;80:73-82. doi: 10.1002/path.1700800109.
2
Healing of hyaluronic acid-enriched wounds: histological observations.富含透明质酸伤口的愈合:组织学观察
J Surg Res. 1983 Nov;35(5):410-6. doi: 10.1016/0022-4804(83)90030-6.
3
The physiology of high altitude.高原生理学。
Sci Am. 1970 Feb;222(2):52-62. doi: 10.1038/scientificamerican0270-52.
4
The neutrophilic leukocyte in wound repair a study with antineutrophil serum.伤口修复中的嗜中性白细胞:一项使用抗中性粒细胞血清的研究
J Clin Invest. 1972 Aug;51(8):2009-23. doi: 10.1172/JCI107007.
5
Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sjögren's syndrome.局部应用纤连蛋白对干燥综合征性角结膜炎患者的有益作用。
J Rheumatol. 1985 Jun;12(3):487-9.
6
Comparison of fetal, newborn, and adult wound healing by histologic, enzyme-histochemical, and hydroxyproline determinations.通过组织学、酶组织化学和羟脯氨酸测定比较胎儿、新生儿和成人的伤口愈合情况。
J Pediatr Surg. 1985 Aug;20(4):315-9. doi: 10.1016/s0022-3468(85)80210-4.
7
A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing.透明质酸和纤维蛋白在炎症反应和伤口愈合早期事件中的作用模型。
J Theor Biol. 1986 Mar 21;119(2):219-34. doi: 10.1016/s0022-5193(86)80076-5.
8
Trophic effect of amniotic fluid on fetal gastrointestinal development.羊水对胎儿胃肠道发育的营养作用。
J Surg Res. 1986 Apr;40(4):291-6. doi: 10.1016/0022-4804(86)90189-7.
9
Diagnosis and management of fetal facial clefts.
Am J Obstet Gynecol. 1986 Aug;155(2):377-9. doi: 10.1016/0002-9378(86)90833-1.
10
Fetal surgery: a frontier for plastic surgery.胎儿外科手术:整形外科学的一个前沿领域。
Plast Reconstr Surg. 1986 Apr;77(4):645-7. doi: 10.1097/00006534-198604000-00024.