Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.
Int J Mol Sci. 2022 Feb 22;23(5):2425. doi: 10.3390/ijms23052425.
Mesenchymal stem/stromal cells (MSCs) are widely described in the context of their regenerative and immunomodulatory activity. MSCs are isolated from various tissues and organs. The most frequently described sources are bone marrow and adipose tissue. As stem cells, MSCs are able to differentiate into other cell lineages, but they are usually reported with respect to their paracrine potential. In this review, we focus on MSCs derived from adipose tissue (AT-MSCs) and their secretome in regeneration processes. Special attention is given to the contribution of AT-MSCs and their derivatives to angiogenic processes described mainly in the context of angiogenic dysfunction. Finally, we present clinical trials registered to date that concern the application of AT-MSCs and their secretome in various medical conditions.
间充质干细胞（MSCs）在其再生和免疫调节活性的背景下被广泛描述。MSCs 从各种组织和器官中分离出来。最常描述的来源是骨髓和脂肪组织。作为干细胞，MSCs 能够分化为其他细胞谱系，但通常是根据它们的旁分泌潜能来报道的。在这篇综述中，我们重点介绍了来源于脂肪组织的 MSCs（AT-MSCs）及其在再生过程中的分泌组。特别关注的是 AT-MSCs 及其衍生物对血管生成过程的贡献，这些过程主要是在血管生成功能障碍的背景下描述的。最后，我们介绍了迄今为止登记的临床试验，这些试验涉及 AT-MSCs 及其分泌组在各种医疗条件下的应用。
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