间充质干细胞及其融合在组织再生中的作用。
The Role of MSCs and Cell Fusion in Tissue Regeneration.
机构信息
Institute of Immunology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448 Witten, Germany.
出版信息
Int J Mol Sci. 2021 Oct 12;22(20):10980. doi: 10.3390/ijms222010980.
Abstract
Regenerative medicine is concerned with the investigation of therapeutic agents that can be used to promote the process of regeneration after injury or in different diseases. Mesenchymal stem/stromal cells (MSCs) and their secretome-including extracellular vesicles (EVs) are of great interest, due to their role in tissue regeneration, immunomodulatory capacity and low immunogenicity. So far, clinical studies are not very conclusive as they show conflicting efficacies regarding the use of MSCs. An additional process possibly involved in regeneration might be cell fusion. This process occurs in both a physiological and a pathophysiological context and can be affected by immune response due to inflammation. In this review the role of MSCs and cell fusion in tissue regeneration is discussed.
摘要
再生医学关注的是研究治疗剂，这些治疗剂可用于促进损伤或不同疾病后的再生过程。间充质干细胞（MSCs）及其分泌组，包括细胞外囊泡（EVs），因其在组织再生、免疫调节能力和低免疫原性方面的作用而备受关注。到目前为止，临床研究还不是非常确定，因为它们在使用 MSCs 方面显示出相互矛盾的疗效。另一个可能参与再生的过程可能是细胞融合。该过程发生在生理和病理生理环境中，并可能受到炎症引起的免疫反应的影响。在这篇综述中，讨论了 MSCs 和细胞融合在组织再生中的作用。
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