氯喹、氯喹的两种对映体、去乙基氯喹及咯萘啶对恶性疟原虫的体外活性
In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.
作者信息
Fu S, Björkman A, Wåhlin B, Ofori-Adjei D, Ericsson O, Sjöqvist F
出版信息
Br J Clin Pharmacol. 1986 Jul;22(1):93-6.
Abstract
A 48 h in vitro test was conducted to compare the susceptibility of two strains of Plasmodium falciparum to chloroquine, the two enantiomers of chloroquine, desethylchloroquine and the new antimalarial drug pyronaridine. The five compounds similarly inhibited the chloroquine sensitive strain. However, desethylchloroquine was less active and pyronaridine was much more active than chloroquine and its enantiomers against the chloroquine resistant strain.
摘要
进行了一项48小时的体外试验，以比较两株恶性疟原虫对氯喹、氯喹的两种对映体、去乙基氯喹和新型抗疟药咯萘啶的敏感性。这五种化合物对氯喹敏感株的抑制作用相似。然而，对于氯喹耐药株，去乙基氯喹的活性较低，而咯萘啶的活性比氯喹及其对映体高得多。
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