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氯喹、氯喹的两种对映体、去乙基氯喹及咯萘啶对恶性疟原虫的体外活性

In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

作者信息

Fu S, Björkman A, Wåhlin B, Ofori-Adjei D, Ericsson O, Sjöqvist F

出版信息

Br J Clin Pharmacol. 1986 Jul;22(1):93-6.

PMID:3527245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1401091/
Abstract

A 48 h in vitro test was conducted to compare the susceptibility of two strains of Plasmodium falciparum to chloroquine, the two enantiomers of chloroquine, desethylchloroquine and the new antimalarial drug pyronaridine. The five compounds similarly inhibited the chloroquine sensitive strain. However, desethylchloroquine was less active and pyronaridine was much more active than chloroquine and its enantiomers against the chloroquine resistant strain.

摘要

进行了一项48小时的体外试验，以比较两株恶性疟原虫对氯喹、氯喹的两种对映体、去乙基氯喹和新型抗疟药咯萘啶的敏感性。这五种化合物对氯喹敏感株的抑制作用相似。然而，对于氯喹耐药株，去乙基氯喹的活性较低，而咯萘啶的活性比氯喹及其对映体高得多。

相似文献

1
In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.氯喹、氯喹的两种对映体、去乙基氯喹及咯萘啶对恶性疟原虫的体外活性
Br J Clin Pharmacol. 1986 Jul;22(1):93-6.
2
[In vitro activity of chloroquine, two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum].[氯喹、氯喹的两种对映体、去乙基氯喹及咯萘啶对恶性疟原虫的体外活性]
Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1986;4(4):269-71.
3
In vitro activity of pyronaridine against African strains of Plasmodium falciparum.咯萘啶对恶性疟原虫非洲株的体外活性。
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本文引用的文献

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[The embryotoxicity of a new antimalarial pyronaridine in rats].[一种新型抗疟药咯萘啶对大鼠的胚胎毒性]
Yao Xue Xue Bao. 1982 Jun;17(6):401-6.
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Am J Trop Med Hyg. 1980 May;29(3):339-42. doi: 10.4269/ajtmh.1980.29.339.
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Chemoprophylaxis of malaria in Africa: the spent "magic bullet".非洲疟疾的化学预防：失效的“神奇子弹”
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In vitro assessment of the antimalarial activity of chloroquine and its major metabolites.氯喹及其主要代谢产物抗疟活性的体外评估
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