Department of Health Sciences, Wuhan Sports University, Wuhan, Hubei, China.
Department of Rehabilitation Medicine, Guizhou Orthopedics Hospital, Guiyang, Guizhou, China
BMJ Open. 2022 Mar 10;12(3):e051630. doi: 10.1136/bmjopen-2021-051630.
Patients with stroke usually suffer from varying degrees of movement dysfunction, which seriously affects their quality of life, especially for the upper limb dysfunction. Therefore, this study aims to compare the effects of different repetitive transcranial magnetic stimulation (rTMS) modalities on upper limb motor function and daily activities in patients with stroke.
Relevant research will be collected systematically from PubMed, Web of Science, Embase, Cochrane Library, ProQuest, Wanfang Database, China National Knowledge Infrastructure and Chinese Scientific and Journal Database (VIP) about randomised controlled trials of rTMS in the stroke treatment range from the establishment to November 2020. Primary outcomes will be obtained from scales measuring the upper limb motor function like Upper Extremity Fugl-Meyer Assessment Scale, Wolf Motor Function Test, Jebsen-Taylor Hand Function Test, Action Research Arm Test and Box and Block Test. The secondary outcomes include modified Barthel Index and adverse events (such as vertigo, headache and epilepsy), with the goal of assessing patients' activities of daily living and the safety of treatment. In order to avoid personal bias in the included studies, two reviewers will conduct the data extraction and quality evaluation independently, and all data analyses will be performed by Generate Mixed Treatment comparison software V.0.14.3 and Stata V.16.0.
The network meta-analysis (NMA) in this study does not require ethical approval because the data analysis will be used only to evaluate the rTMS treatment efficacy without patients' private information. In addition, the results will be disseminated in international conference reports and peer-reviewed manuscripts.
CRD42020212253.
脑卒中患者常伴有不同程度的运动功能障碍，严重影响其生活质量，尤其是上肢运动功能障碍。因此，本研究旨在比较不同重复经颅磁刺激（rTMS）模式对脑卒中患者上肢运动功能和日常生活活动的影响。
将从建库至 2020 年 11 月，在 PubMed、Web of Science、Embase、Cochrane Library、ProQuest、万方数据库、中国知网和中文科技期刊数据库（VIP）中系统收集 rTMS 治疗脑卒中的随机对照试验相关研究。主要结局将通过上肢运动功能量表（如上肢 Fugl-Meyer 评定量表、Wolf 运动功能测试、Jebsen-Taylor 手功能测试、动作研究上肢测试和方块和木块测试）获得。次要结局包括改良 Barthel 指数和不良事件（如眩晕、头痛和癫痫），以评估患者的日常生活活动和治疗安全性。为避免纳入研究中的个人偏见，两位评审员将独立进行数据提取和质量评估，所有数据分析将由 Generate Mixed Treatment comparison software V.0.14.3 和 Stata V.16.0 进行。
本研究中的网络荟萃分析（NMA）不需要伦理批准，因为数据分析仅用于评估 rTMS 治疗效果，不涉及患者的个人隐私。此外，研究结果将以国际会议报告和同行评议的论文形式发表。
PROSPERO 注册号：CRD42020212253。
