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微循环与组织氧合监测有哪些新进展?

What is new in microcirculation and tissue oxygenation monitoring?

作者信息

de Keijzer Ilonka N, Massari Dario, Sahinovic Marko, Flick Moritz, Vos Jaap Jan, Scheeren Thomas W L

机构信息

University Medical Center Groningen, Groningen, The Netherlands.

Department of Anesthesiology, Center of Anesthesiology and Intensive Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

J Clin Monit Comput. 2022 Apr;36(2):291-299. doi: 10.1007/s10877-022-00837-x. Epub 2022 Mar 11.

Abstract

Ensuring and maintaining adequate tissue oxygenation at the microcirculatory level might be considered the holy grail of optimal hemodynamic patient management. However, in clinical practice we usually focus on macro-hemodynamic variables such as blood pressure, heart rate, and sometimes cardiac output. Other macro-hemodynamic variables like pulse pressure or stroke volume variation are additionally used as markers of fluid responsiveness. In recent years, an increasing number of technological devices assessing tissue oxygenation or microcirculatory blood flow have been developed and validated, and some of them have already been incorporated into clinical practice. In this review, we will summarize recent research findings on this topic as published in the last 2 years in the Journal of Clinical Monitoring and Computing (JCMC). While some techniques are already currently used as routine monitoring (e.g. cerebral oxygenation using near-infrared spectroscopy (NIRS)), others still have to find their way into clinical practice. Therefore, further research is needed, particularly regarding outcome measures and cost-effectiveness, since introducing new technology is always expensive and should be balanced by downstream savings. The JCMC is glad to provide a platform for such research.

摘要

在微循环水平确保并维持充足的组织氧合或许可被视为优化患者血流动力学管理的圣杯。然而,在临床实践中,我们通常关注诸如血压、心率等宏观血流动力学变量,有时也关注心输出量。诸如脉压或每搏量变异等其他宏观血流动力学变量还被用作液体反应性的指标。近年来,越来越多评估组织氧合或微循环血流的技术设备得到开发和验证,其中一些已被纳入临床实践。在本综述中,我们将总结过去两年发表在《临床监测与计算杂志》(JCMC)上关于该主题的最新研究发现。虽然一些技术目前已被用作常规监测(例如使用近红外光谱法(NIRS)进行脑氧合监测),但其他技术仍有待进入临床实践。因此,需要进一步研究,特别是在结局指标和成本效益方面,因为引入新技术总是昂贵的,应该通过下游的节省来平衡。JCMC很高兴为此类研究提供一个平台。

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