State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
J Nat Prod. 2011 Dec 27;74(12):2571-5. doi: 10.1021/np200755t. Epub 2011 Dec 7.
Six novel Ia₃-type cyclopeptide alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11β-HSD1, with IC₅₀ values of 52.0 (human) and 31.2 μg/mL (mouse).
从酸枣茎中分离得到 6 种新型 Ia₃ 型环肽生物碱（1-6）。化合物 5 和已知化合物 Mauritine A（7）和 Mauritine F（8）从根部分离得到。通过光谱分析和化学方法确定了它们的结构。对根总生物碱和分离得到的环肽生物碱进行了抗抑郁行为、细胞毒性和体外 11β-羟甾类脱氢酶（11β-HSD）抑制活性测试。只有 Mauritine A（7）对 11β-HSD1 具有抑制活性，其 IC₅₀ 值分别为 52.0（人）和 31.2 μg/mL（鼠）。
