Third Department of Internal Medicine - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, University Hospital and Palacky University, Olomouc, Czech Republic.
Physiol Res. 2022 Apr 30;71(2):275-284. doi: 10.33549/physiolres.934854. Epub 2022 Apr 11.
Wnt1 inducible protein-1 signaling pathway (WISP-1) is a relatively new adipokine involved in many cellular processes, including epithelial mucosa healing. The aim of the study was to compare circulating levels of WISP-1 and other selected adipokines [adiponectin, resistin and retinol-binding protein 4 (RBP-4)] in children with inflammatory bowel disease (IBD) with healthy controls and to investigate possible differences between Crohn's disease patients. (CD) or ulcerative colitis (UC). The study was performed as a case-control study. In addition to adipokines, anthropometric, lipid parameters, markers of inflammation or disease activity were evaluated in all participants. Compared to healthy controls (n=20), significantly lower levels of adiponectin and higher levels of resistin and WISP-1 were found in patients with IBD (n=58). Elevation of WISP-1 was detected only in the CD group (n=31). There were no differences in RBP-4 levels between the groups. Adiponectin, WISP-1 and RBP-4 were independently associated with body mass index only, resistin levels were associated with C-reactive protein levels and leukocyte counts. Adverse adipokines production reflects presence of dysfunctional fat tissue in IBD patients. Higher levels of WISP-1 in CD compared to patients with UC may indicate a specific role for mesenteric adipose tissue in WISP-1 production.
Wnt1 诱导蛋白-1 信号通路（WISP-1）是一种相对较新的脂肪因子，参与许多细胞过程，包括上皮黏膜愈合。本研究旨在比较炎症性肠病（IBD）患儿与健康对照组循环中 WISP-1 和其他选定脂肪因子[脂联素、抵抗素和视黄醇结合蛋白 4（RBP-4）]的水平，并探讨克罗恩病（CD）或溃疡性结肠炎（UC）患者之间的可能差异。本研究为病例对照研究。除脂肪因子外，还评估了所有参与者的人体测量、脂质参数、炎症或疾病活动标志物。与健康对照组（n=20）相比，IBD 患者（n=58）的脂联素水平显著降低，抵抗素和 WISP-1 水平显著升高。仅在 CD 组（n=31）检测到 WISP-1 升高。各组间 RBP-4 水平无差异。脂联素、WISP-1 和 RBP-4 仅与体重指数独立相关，抵抗素水平与 C 反应蛋白水平和白细胞计数相关。不良脂肪因子的产生反映了 IBD 患者功能性脂肪组织的存在。与 UC 患者相比，CD 中更高水平的 WISP-1 可能表明肠系膜脂肪组织在 WISP-1 产生中具有特定作用。
