Department of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, United States of America; VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, United States of America.
VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, United States of America.
Int J Cardiol. 2022 May 15;355:23-27. doi: 10.1016/j.ijcard.2022.03.010. Epub 2022 Mar 9.
Delayed time of evening meal is associated with favorable cardiorespiratory fitness (CRF) in patients with heart failure with preserved ejection fraction (HFpEF) and obesity. It is unknown, however, if increasing daily non-fasting time or delaying the midpoint of energy intake may also be associated with CRF.
Our aim was to examine whether a longer non-fasting time, delayed midpoint of energy intake, or both, are associated with greater CRF in patients with HFpEF and obesity.
We measured peak oxygen consumption (VO), a measure of CRF, in 32 patients with HFpEF and obesity with cardiopulmonary exercise testing, and dietary intake using a five-pass 24-h dietary recall. Participants were divided into groups by having lesser (<11.6) or greater (≥11.6) periods of non-fasting time than the median and similarly, with earlier (<2:15 PM) or later (≥2:15 PM) than median midpoint of energy intake.
Median non-fasting time was 11.6 [10.6-12.9] hours and midpoint of energy intake was 2:15 [1:04-3:00] PM. There were no differences in CRF between those with a shorter (<11.6) or longer (≥11.6) non-fasting time. Participants with a delayed midpoint of energy intake (≥2:15 PM) had greater peak VO and exercise time. Midpoint of energy intake (r = 0.444, P = 0.011) and time of last meal (r = 0.550, P = 0.001) displayed a positive association with peak VO, but not non-fasting time nor time of first meal.
Delaying the midpoint of energy intake by postponing last meal is associated with better peak VO and exercise time in patients with HFpEF and obesity.
对于射血分数保留的心力衰竭（HFpEF）合并肥胖患者，晚餐时间延迟与心肺呼吸适能（CRF）呈正相关。然而，目前尚不清楚增加每日非禁食时间或延迟能量摄入的中点是否也与 CRF 相关。
我们旨在探讨 HFpEF 合并肥胖患者中非禁食时间延长、能量摄入中点延迟或两者与 CRF 增加的相关性。
我们使用心肺运动试验测量了 32 名 HFpEF 合并肥胖患者的最大摄氧量（VO2，CRF 的衡量指标），并使用 5 次 24 小时饮食回忆法测量了饮食摄入量。参与者根据非禁食时间（中位数为 11.6 小时）分为非禁食时间较少（<11.6 小时）和较多（≥11.6 小时）两组，同样根据能量摄入中点（中位数为下午 2:15）分为较早（<2:15 PM）和较晚（≥2:15 PM）两组。
非禁食时间的中位数为 11.6 [10.6-12.9] 小时，能量摄入中点为下午 2:15 [1:04-3:00]。非禁食时间较短（<11.6 小时）和较长（≥11.6 小时）的两组间 CRF 无差异。能量摄入中点较晚（≥2:15 PM）的患者具有更大的 VO2 峰值和运动时间。能量摄入中点（r=0.444，P=0.011）和最后一餐时间（r=0.550，P=0.001）与 VO2 峰值呈正相关，但与非禁食时间或第一餐时间无关。
通过推迟最后一餐来延迟能量摄入的中点与 HFpEF 合并肥胖患者的 VO2 峰值和运动时间改善相关。
