Althubeati Sarah, Avery Amanda, Tench Christopher R, Lobo Dileep N, Salter Andrew, Eldeghaidy Sally
Division of Food, Nutrition & Dietetics, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK; Faculty of Applied Medical Sciences, Department of Clinical Nutrition, King Abdulaziz University, Jeddah, Saudi Arabia.
Division of Food, Nutrition & Dietetics, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK.
Neurosci Biobehav Rev. 2022 May;136:104603. doi: 10.1016/j.neubiorev.2022.104603. Epub 2022 Mar 9.
Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show inconsistency across functional neuroimaging studies. The aim of this study was to systematically assess the convergence of brain regions modulated by appetite and satiety regulators. Twenty-five studies were considered for qualitative synthesis, and 14 independent studies (20-experiments) found eligible for coordinate-based neuroimaging meta-analyses across 212 participants and 123 foci. We employed two different meta-analysis approaches. The results from the systematic review revealed the modulation of insula, amygdala, hippocampus, and orbitofrontal cortex (OFC) with appetite regulators, where satiety regulators were more associated with caudate nucleus, hypothalamus, thalamus, putamen, anterior cingulate cortex in addition to the insula and OFC. The two neuroimaging meta-analyses methods identified the caudate nucleus as a key area associated with satiety regulators. Our results provide quantitative brain activation maps of neurohormonal gut-brain signaling in heathy-weight adults that can be used to define alterations with eating behavior.
了解神经激素肠-脑信号如何调节食欲和饱腹感对于肥胖及饮食行为改变的治疗发展至关重要。然而，在功能性神经影像学研究中，已报道的与食欲或饱腹感调节因子相关的脑区存在不一致性。本研究的目的是系统评估由食欲和饱腹感调节因子调节的脑区的一致性。25项研究被纳入定性综合分析，14项独立研究（20项实验）被认为符合基于坐标的神经影像学荟萃分析的条件，涉及212名参与者和123个焦点。我们采用了两种不同的荟萃分析方法。系统评价的结果显示，食欲调节因子可调节脑岛、杏仁核、海马体和眶额皮质（OFC），而饱腹感调节因子除了与脑岛和OFC相关外，还与尾状核、下丘脑、丘脑、壳核、前扣带回皮质更相关。两种神经影像学荟萃分析方法均将尾状核确定为与饱腹感调节因子相关的关键区域。我们的研究结果提供了健康体重成年人神经激素肠-脑信号的定量脑激活图谱，可用于确定饮食行为的改变。
