Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece.
Oncology Department of Daily Hospitality, Laiko General Hospital, 11527 Athens, Greece.
Nutrients. 2022 Jan 19;14(3):442. doi: 10.3390/nu14030442.
The present cross-sectional prospective study (from January 2017 until December 2020) aimed to evaluate the interrelation between nutritional parameters at the initial evaluation with the changes in QOL indicators and the Progression-Free Survival and Overall Survival in 97 patients with pancreatic cancer. Dietary and nutritional risk assessments, and an evaluation of Frailty and Functional Status were performed. Health-related Quality of Life was evaluated with the EORTC QLQ-C30 questionnaire. Nutritional risk, as evaluated by MNA-SF score, was negatively associated with age (p = 0.003) and positively associated with dynamometry (p = 0.001). In addition, there was a statistically significant difference in the financial difficulties (p = 0.049). OS and PFS were found to decrease in patients who reported having increased fatigue (OS p = 0.007 and PFS p = 0.044). Moreover, higher prevalence of constipation resulted in lower OS and PFS (OS p < 0.001 and PFS p < 0.001) and increased reporting of gastrointestinal problems during the 3 months was connected with lower survival (OS p = 0.017). According to the analysis, our patients were found to have lower OS and PFS, stressing out the necessity to provide early identification and management to symptoms of the disease that could compromise nutritional status. The provision of nutritional advice and guidance is of major importance for patients.
本横断面前瞻性研究（2017 年 1 月至 2020 年 12 月）旨在评估 97 例胰腺癌患者初始评估时的营养参数与生活质量指标变化、无进展生存期和总生存期之间的相互关系。进行了膳食和营养风险评估以及虚弱和功能状态评估。采用 EORTC QLQ-C30 问卷评估健康相关生活质量。MNA-SF 评分评估的营养风险与年龄呈负相关（p = 0.003），与握力呈正相关（p = 0.001）。此外，在经济困难方面存在统计学差异（p = 0.049）。在报告疲劳增加的患者中，OS 和 PFS 降低（OS p = 0.007 和 PFS p = 0.044）。此外，更高的便秘发生率导致 OS 和 PFS 降低（OS p < 0.001 和 PFS p < 0.001），并且在 3 个月期间报告胃肠道问题增加与生存率降低相关（OS p = 0.017）。根据分析，我们的患者发现 OS 和 PFS 较低，强调需要早期识别和管理可能影响营养状况的疾病症状。为患者提供营养建议和指导非常重要。
